Novel Methods for Measuring Depth of Anesthesia by Quantifying Dominant Information Flow in Multichannel EEGs

Figure 2

Example of mutual information and transfer entropy using clinical EEG data (the two vertical dashed lines indicate and corresponding to LOC and ROC, resp.). (a) Raw multichannel EEGs for 140 min before and after anesthesia, (b) plasma concentration of propofol (infusion rate = 12 mg/kg/h), (c) mutual information between frontal lobe (F3) and parietal lobe (P3), (d) transfer entropy in feedback pathway (), and (e) transfer entropy in feedforward pathway ().

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