Review Article

Emergence of Deep Learning in Knee Osteoarthritis Diagnosis

Table 6

Summary of 2D CNN classification approaches on grading of osteoarthritis severity.

Publication referenceTarget tasksModality (imaging sequence)Data setNetwork architecturePerformance

Tiulpin et al. [16]Predict knee OA severity based on KL-gradeX-ray (plain radiography)MOST: 18376 images (training),Deep Siamese convolutional neural networkAUC: 0.93
OAI: 2957 images (validation), 5960 images (testing)

Nguyen et al. [57]Predict knee OA severity based on KL-gradeX-ray (plain radiography)OAI: 39,902 images (training)Deep Siamese convolutional neural network with pi-model approachCohen’s Kappa coefficient (KC): 0.790
MOST: 3,445 images (testing)Balanced accuracy (BA): 0.527

Nguyen et al. [23]Predict knee OA severity based on KL-gradeX-ray (plain radiography)OAI: 39902 images (training/validating)Semixup (Siamese network + novel deep semisupervised learning)Balanced accuracy ± SD: 71 ± 0.8%
MOST: 3445 images (testing)

Liu et al. [58]Predict knee OA severity based on KL-gradeX-ray (plain radiography)2770 imagesFaster R-CNN (region proposal network + Fast R–CNN) + focal lossAccuracy: 82.5%; SN: 78.2%; SP: 94.8%
Antony et al. [30]Predict knee OA severity based on KL-gradeX-ray (plain radiography)OAI: 8892 imagesVGG16, VGG-M-128, and BVLCMean squared error: 0.504 (CNN-Reg)
CaffeNet

Norman et al. [5]Predict knee OA severity based on KL-gradeX-ray (plain radiography)OAI: 39,593 images (25,873 training, 7779 validation, 5941 testing)DenseNetSN: 83.7 (no OA), 70.2 (mild OA), 68.9 (moderate OA), 86.0 (severe OA) %
SP: 86.1 (no OA), 83.8 (mild OA), 97.1 (moderate OA), 99.1 (severe OA) %

Zhang et al. [59]Predict knee OA severity based on KL-gradeX-ray (plain radiography)OAI: (38232 training, 10986 testing, 5422 validation) imagesResNet with convolutional block attention module (CBAM)Accuracy: 74.81%; mean squared error: 0.36; quadratic Kappa score: 0.88
Leung et al. [60]Predict knee OA severity based on KL-grade and predict total knee replacementX-ray (plain radiography)OAI: 728 subjectsResNet-34 (ResNet with 34 layers)AUC: 0.87
Tiulpin and Saarakkala [26]Predict knee OA severityX-ray (plain radiography)OAI: 19704 images (training); MOST: 11743 (testing)SE-ResNet-50 + SE-ResNet-50-32 × 4d (SE-ResNet-50 with ResNeXt blocks)AUC: 0.98
Kim et al. [17]Predict knee OA severity based on KL-gradeX-ray (plain radiography)4366 images (3464 training, 386 validation, 516 testing)Six SE-ResNetAUC: 0.97 (KL 0), 0.85 (KL1), 0.75 (KL2), 0.86 (KL3), 0.95 (KL4)
Chen et al. [34]Predict knee OA severity based on KL-gradeX-ray (plain radiography)OAI: 4130 images (training : validation : testing; 7 : 1 : 2)VGG-19 + proposed ordinal lossAccuracy: 70.4%; mean absolute error (MAE): 0.358
Pedoia et al. [61]Predict presence of OAMRI (T2 mapping acquisition)OAI: 4384 subjectsDenseNetAUC: 83.44%; SN: 76.99%; SP: 77.94%

Note. Modality (imaging sequence): magnetic resonance imaging (MRI); data set: Osteoarthritis Initiative (OAI); network architecture: convolutional neural network (CNN) and squeeze-and-excitation (SE); performance: specificity (SP), sensitivity (SN), area under receiver operating characteristics curve (AUC), and standard deviation (SD).