Quercetin Promotes TFEB Nuclear Translocation and Activates Lysosomal Degradation of Ferritin to Induce Ferroptosis in Breast Cancer Cells

Figure 3

Quercetin regulates TFEB and promotes the release of iron ions from lysosomes. (a) MCF-7 cells were treated with NC or TFEB siRNA, respectively, and TFEB protein expression level was detected. MCF-7 cells were incubated with quercetin, TFEB siRNA, and chloroquine alone or co-incubated to detect intracellular ferritin expression (b), iron ion levels (c), and cell viability (d). , , and .

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