A Complex Heterogeneous Network Model of Disease Regulated by Noncoding RNAs: A Case Study of Unstable Angina Pectoris

Table 3

Comparison of the performance of hub miRNAs obtained by several network analysis methods.

		WGCNA	FC_hub	SimCluster_1	WGCNA & SimCluster_1	SimCluster_2	WGCNA & SimCluster_2
Original dataset	Mean_AUC	0.5071	0.9083	0.5771	0.6190	0.5884	0.9905
	Mean_AUPR	0.6689	0.9118	0.6620	0.7112	0.6679	0.9911
New dataset	Mean_AUC	0.5191	0.5197	0.5319	0.6292	0.5166	0.5296
	Mean_AUPR	0.6019	0.5862	0.6069	0.6773	0.5960	0.6026

Note. FC_hub refers to the top 20 miRNAs ranked by |logFC|. SimCluster_1 and SimCluster_2 refer to the results obtained based on first-order similarity and second-order similarity, respectively. “&” refers to the results of the intersection of the two methods. Bold values indicate the best results on the new dataset.