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Canadian Journal of Gastroenterology
Volume 2, Issue 1, Pages 31-34
Brief Communication

Hypothalamic Hypogonadism in Hemochromatosis: A Case Report

Igor Matwijiw, Gerald D. Iliffe, Adi E. Mehta, and Charles Faiman

Departments of Medicine and Physiology, University of Manitoba and the Endocrine-Metabolic Laboratory, Health Sciences Centre, Winnipeg, Canada

Received 14 August 1987; Accepted 28 October 1987

Copyright © 1988 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A 42-year-old man developed hypogonadotropic hypogonadism due to primary hemochromatosis. Endocrine evaluation indicated a hypothalamic defect in the control of gonadotropin secretion. Although cirrhosis was present on liver biopsy, ocher major features of the hemochromatosis syndrome were not manifest. Patients with hemochromacosis arc now being diagnosed at earlier stages of disease. Clinicians should be alert to possible early development of hypothalamopituitary dysfunction and should be prepared co perform derailed endocrinological investigations in such patients.