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Canadian Journal of Gastroenterology
Volume 2 (1988), Issue 1, Pages 22-27
http://dx.doi.org/10.1155/1988/218728
Clinical Gastroenterology

Autoimmune Chronic Active Hepatitis (Lupoid Hepatitis) and Primary Sclerosing Cholangitis in Two Young Adult Females

Gerald Y. Minuk,1 Lloyd R. Sutherland,1 S. Chris Pappas,2 James K. Kelly,1 and Sue E. Martin2

1Department of Medicine, University of Calgary, Calgary, Alberta, Canada
2Liver Disease Section, Digestive Diseases Branch NIADDK, National Institutes of Health, Bethesda, Maryland, USA

Received 1 October 1987; Accepted 1 December 1987

Copyright © 1988 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Autoimmune chronic active hepatitis (CAH) and primary sclerosing cholangitis (PSC) arc chronic diseases of the hepatobiliary system that have many clinical, immunologic and genetic features in common. Despite these similarities, there are few reports of the two diseases coexisting. Two young women with clinical, biochemical, serologic, radiologic and histologic findings compatible with both autoimmune CAH and PSC are described. The observation that there may be a striking overlap in the features of these two diseases and recent improvements in diagnostic imaging of the biliary tract suggest that the association of these two diseases in the same individual may be more common than is presently appreciated.