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Canadian Journal of Gastroenterology
Volume 4, Issue 7, Pages 415-416
IDB: Trends in Medical Therapy

Budesonide Enemas for Topical Therapy of Ulcerative Colitis

P Rutgeerts

Department of Medicine, University Hospital of Gasthuisberg, Leuven, Belgium

Copyright © 1990 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Budesonide is a nonhalogenated glucocorticosteroid that is very suitable for topical therapy in left-sided colitis because it has a high ratio of topical to systemic activity. Although it is absorbed, it is very rapidly metabolized by the liver (first pass metabolism). It does not suppress the hypothalamic-pituitary axis. Budesonide has been shown to be more effective than placebo and predinsolone enemas for the treatment of left-sided ulcerative colitis.