Canadian Journal of Gastroenterology and Hepatology

Canadian Journal of Gastroenterology and Hepatology / 1990 / Article

Review | Open Access

Volume 4 |Article ID 719831 |

PK Rangachari, "Six-Pack Balancing Act: A Conceptual Model for the Intestinal Lining", Canadian Journal of Gastroenterology and Hepatology, vol. 4, Article ID 719831, 8 pages, 1990.

Six-Pack Balancing Act: A Conceptual Model for the Intestinal Lining

Received05 Feb 1990
Accepted20 Mar 1990


The cells chat form the lining of the intestine belong to a class of cells termed 'polarized' or 'asymmetric.' The membranes surrounding these cells show functional differences at the luminal and contraluminal surfaces. The cells line up to form sheets and it is across these sheers that movement of fluids and solutes occurs. Such movement occurs in both directions across the lining and the occurrence of diarrhea or constipation depends to a considerable extent upon the net result of the absorptive and secretory mechanisms and their modulation by a host of factors such as neurotransmitters, bacterial products, drugs, etc. This review provides a simple framework for understanding the dynamics of the gut lining. Diamond's six-pack model of epithelia is modified to include the dynamic tension between absorptive and secretory mechanisms.

Copyright © 1990 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

More related articles

 PDF Download Citation Citation
 Order printed copiesOrder

Related articles

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.