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Canadian Journal of Gastroenterology
Volume 4, Issue 6, Pages 237-242

Helicobacter (Campylobacter) pylori and Acid Peptic Diseases

Sigmund Kradjen and Philip Sherman

St Joseph’s Health Centre and Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

Received 15 March 1990; Accepted 31 July 1990

Copyright © 1990 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Helicobacter pylori is a spiral-shaped Gram-negative bacteria implicated as a cause of histological gastritis, contributing to peptic ulcer disease and perhaps playing a role in gastric cancer in humans. The organism is found worldwide; the prevalence of infection increases with age; and colonization probably persists for life. Diagnostic approaches chat have been used include tissue stains, culture of stomach biopsy specimens, labelled-urea breath tests and serology. It is too early to advocate treatment for all infected individuals; the benefits and risks have yet to be carefully studied and assessed.