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Canadian Journal of Gastroenterology
Volume 8, Issue 4, Pages 235-238
http://dx.doi.org/10.1155/1994/151096
Clinical Gastroenterology

Positive Correlation between Normal Serum Gastrin Concentrations and Antral and Duodenal G Cells

WR Yacoub, ABR Thomson, RW Sherbaniuk, P Hooper, and LD Jewell

Departments of Pathology and Medicine (Division of Gastroenterology) and the Department of Statistics and Applied Probability, University of Alberta, Edmonton, Alberta, Canada

Received 13 September 1993; Accepted 14 January 1994

Copyright © 1994 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

It is controversial whether there is a correlation between serum gastrin concentrations and the density of G cells in the antral or duodenal mucosa. In this study, endoscopically obtained antral and duodenal biopsies were stained immunocytochemically for gastrin and the G cells quantitated using an MOP Videoplan computer image analysis system. Studies were performed in 20 patients with acid-peptic disorders (gastric ulcer, n=5; duodenal ulcer, n=10; reflux esophagitis, n=4; and nonulcer dyspepsia, n=1). Correlations between antral and duodenal G cell densities, and basal- and food-stimulated serum gastrin concentrations within the normal range (less than 100 mg/L) – but not in those with elevated gastrin concentrations – support the postulate that alterations in G cell function are important in patients with acid-peptic disorders.