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Canadian Journal of Gastroenterology
Volume 8, Issue 7, Pages 408-412
Clinical Gastroenterology

Detection of Antibody against Helicobacter pylori in the Saliva of Patients with Dyspepsia

Robert L Clancy,1 Allan W Cripps,1 Diana C Taylor,1 Lois A McShane,1 and Victor J Webster1

1Faculty of Medicine, University of Newcastle, Newcastle, New South Wales, Australia
2Australian Institute of Mucosal Immunology, Newcastle, New South Wales, Australia
3Warners Bay Endoscopy, Warners Bay, New South Wales, Australia

Received 12 April 1994; Accepted 21 July 1994

Copyright © 1994 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


There is a need to develop noninvasive assays to detect Helicobacter pylori infection in the gastric mucosa, Current dogma predicts that the presence of antibody within saliva should accurately reflect contemporary colonization of the gut mucosa. This study examined the clinical value of a saliva enzyme-linked immunoadsorbent assay (ELISA) for anti-H pylori antibody, compared with the serum ELISA assay, and found the sensitivity of the saliva assay was 89%, specificity 94%, accuracy 93%, positive predictive value 89% and negative predictive value 94%. Assessment following eradication therapy demonstrated that salivary antibody was a more sensitive indicator of colonization than was serum antibody. The immunoglobulin G antibody in saliva correlated best with colonization, and regression analysis was most consistent with a local production of antibody. These results indicate that detection of antibody in saliva contributes to diagnosis and management of H pylori infection.