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Canadian Journal of Gastroenterology
Volume 8, Issue 6, Pages 373-378
IBD – Therapeutics

Novel Targets for Anti-Inflammatory Therapy in Inflammatory Bowel Disease

John L Wallace

Intestinal Diseases Research Group, University of Calgary, Calgary, Alberta, Canada

Copyright © 1994 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Until the cause(s) of inflammatory bowel disease are identified, improvements in therapy will likely come from improved anti-inflammatory therapy or improved drug delivery systems. There are many potential targets for anti-inflammatory therapy, including the synthesis of specific inflammatory mediators. This review focuses on the potential for developing therapy aimed at three targets: nerves and neuropeptides; coagulation and thrombosis; and adhesion molecules. In each case, evidence is presented from clinical and/or experimental studies that supports the hypothesis that these are rational targets for anti-inflammatory drug development.