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Canadian Journal of Gastroenterology
Volume 9, Issue 6, Pages 319-326

Treatment of Fulminant Hepatic Failure – Is There Light at the End of the Tunnel?

KDE Kaita

Liver Diseases Unit, Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada

Received 11 October 1994; Accepted 10 March 1995

Copyright © 1995 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A lot of research has been done on fulminant hepatic failure (FHF), mainly because of the high mortality associated with it. Many centres continue to search actively for the ideal medical treatment for FHF because liver transplantation is often difficult in these very ill patients. The many forms of therapy that have been tried and reported in case reports, small clinical trials and the occasional randomized controlled trial are reviewed, as are the current data on bioartificial livers and isolated hepatocyte transplantation. The ideal treatment remains elusive, and more work needs to be done to find a highly effective form of therapy for these very ill FHF patients.