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Canadian Journal of Gastroenterology
Volume 11, Issue 3, Pages 243-248
http://dx.doi.org/10.1155/1997/149734
Pediatric Gastroenterology

Adherence of Helicobacter pylori to the Gastric Mucosa

Marguerite Clyne and Brendan Drumm

Department of Paediatrics, University College Dublin, The Children’s Research Centre, Our Lady’s Hospital for Sick Children, Crumlin, Dublin, Ireland

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Bacterial adhesion to the intestinal epithelium is a critical initial step in the pathogenesis of many enteric diseases. Helicobacter pylori is a duodenal pathogen that adheres to the gastric epithelium and causes gastritis and peptic ulceration. The mechanism by which H pylori causes disease has not yet been elucidated but adherence to the gastric mucosa is thought to be an important virulence determinant of the organism. What is known about adherence of H pylori to the gastric mucosa is summarized. Topics discussed are the mechanism of H pylori adherence; in vitro and in vivo models of H pylori infection; and adherence and potential adhesins and receptors for H pylori.