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Canadian Journal of Gastroenterology
Volume 11, Issue 1, Pages 31-34
Brief Communication

Clinical, Pathological and Molecular Genetic Findings in Small Intestinal Follicle Centre Cell Lymphoma

Hugh J Freeman, Michelle E Anderson, and Randy D Gascoyne

Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, British Columbia, Canada

Received 28 November 1995; Accepted 5 February 1996

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A 44-year-old male was evaluated for an iron deficiency anemia. Endoscopic investigation revealed marked serpiginous ulceration of the proximal small intestine due to a B cell lymphoma. Endoscopic small intestinal mucosal biopsies revealed a nodular lymphoid infiltrate, and polymerase chain reaction of biopsy material from the same site demonstrated rearrangement of the bcl-2 gene, the molecular equivalent of the t(14;18) chromosomal translocation. Primary small bowel follicular small cleaved cell lymphoma was diagnosed. Endoscopic tissue biopsies for immunophenotyping, molecular genetic studies or both are a valuable diagnostic aid for precise classification of lymphoid neoplasms in the gastrointestinal tract.