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Canadian Journal of Gastroenterology
Volume 11, Issue 5, Pages 421-423
Clinical Gastroenterology

Hereditary Colon Cancer

Dawna M Gilchrist

Departments of Medicine and Medical Genetics, University of Alberta, Edmonton, Alberta, Canada

Received 10 December 1996; Accepted 4 March 1997

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hereditary colon cancer comprises approximately 10% of total colon cancer, a disease that affects 6% of the North American population. Knowledge of molecular genetics of familial adenomatous polyposis and hereditary nonpolyposis colon cancer has improved our diagnostic abilities and management, as well as furthered our understanding of the mechanisms of tumour initiation and progression.