Canadian Journal of Gastroenterology and Hepatology

Canadian Journal of Gastroenterology and Hepatology / 1998 / Article

Original Article | Open Access

Volume 12 |Article ID 213028 | https://doi.org/10.1155/1998/213028

Edemariam Tsega, John Horton, Erik Nordenfelt, B-J Hansson, Belachew Tafesse, Gizachew Wolde-Hawariat, Johan Lindberg, "Antibody Levels in Ethiopian Children Five Years after Vaccination with Two Different Doses of Hepatitis B Vaccine: Is There a Need for Booster Vaccine?", Canadian Journal of Gastroenterology and Hepatology, vol. 12, Article ID 213028, 4 pages, 1998. https://doi.org/10.1155/1998/213028

Antibody Levels in Ethiopian Children Five Years after Vaccination with Two Different Doses of Hepatitis B Vaccine: Is There a Need for Booster Vaccine?

Received04 Sep 1997
Accepted17 Nov 1997

Abstract

It was hypothesized that, following effective initial vaccination, a booster dose of hepatitis B vaccine will not be necessary in areas of hyperendemicity for hepatitis B virus (HBV) infection. A total of 314 Ethiopian children, ranging from two to 14 years old, were alternatively vaccinated with 10 and 20 µg hepatitis B vaccine doses, using the initial, one- and six-month schedule. Five years later, 210 of the vaccinees were retested for anti-HBV surface antibody titres. Both 10 and 20 µg doses of hepatitis B rDNA yeast vaccine were equally immunogenic and protective against HBV infection for at least five years despite marked reduction of mean antibody levels and geometric mean titres, with 11% of the vaccinees showing antibodies below the protective level. For firm further recommendations a longer follow-up period of vaccinees is suggested.

Copyright © 1998 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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