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Canadian Journal of Gastroenterology
Volume 13, Issue 1, Pages 31-37
http://dx.doi.org/10.1155/1999/457315
Original Article

Intestinal Permeability before and after Ibuprofen in Families of Children with Crohn’s Disease

Samuel A Zamora,1 Robert J Hilsden,2 Jon B Meddings,3 J Decker Butzner,1 R Brent Scott,1 and Lloyd R Sutherland2

1Department of Pediatrics, Health Science Centre, Calgary, Alberta, Canada
2Department of Community Health Sciences, Health Science Centre, Calgary, Alberta, Canada
3Department of Medicine, Health Science Centre, Calgary, Alberta, Canada

Received 11 March 1998; Accepted 7 July 1998

Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

BACKGROUND: Members of a subset of first-degree relatives of adults with Crohn’s disease have been shown to have an increased baseline intestinal permeability and/or an exaggerated increase in intestinal permeability after the administration of acetylsalicylic acid.

PURPOSE: To determine intestinal permeability in unaffected first-degree relatives of children with Crohn’s disease before and after the administration of an ibuprofen challenge.

METHODS: Lactulose-mannitol ratios, a measure of intestinal permeability, were determined in 14 healthy control families (41 subjects) and 14 families with a child with Crohn’s disease (36 relatives, 14 probands) before and after ingestion of ibuprofen. An upper reference limit was defined using the control group as mean ± 2 SD.

RESULTS: The proportion of healthy, first-degree relatives with an exaggerated response to ibuprofen (20%, 95% CI 7% to 33%) was significantly higher than controls (P=0.003). The exaggerated response was more common among siblings than among parents of pediatric probands.

CONCLUSIONS: Members of a subset of first-degree relatives of children with Crohn’s disease have an exaggerated increase in intestinal permeability after ibuprofen ingestion. These findings are compatible with there being a genetic link between abnormalities of intestinal permeability and Crohn’s disease.