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Canadian Journal of Gastroenterology
Volume 13, Issue 7, Pages 613-617
http://dx.doi.org/10.1155/1999/545427

Determinants of Disease Outcome following Helicobacter pylori Infection in Children

Nicola L Jones,1,2 Andrew S Day,2 and Philip M Sherman1,2

1Division of Gastroenterology/Nutrition, Research Institute, The Hospital for Sick Children, Department of Molecular Microbiology and Medical Genetics, University of Toronto, Toronto, Ontario, Canada
2Division of Gastroenterology/Nutrition, Research Institute, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada

Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Helicobacter pylori infection is primarily acquired during childhood, causes chronic, active gastritis and peptic ulcer disease, and is associated with the development of gastric malignancies. However, only a small number of infected individuals ever develop the more severe sequelae of peptic ulcer disease and gastric cancers. Therefore, the identification of bacterial and host factors that play a role in determining the outcomes and pathophysiology of infection is a major focus of current research. Recent advances in the understanding of disease pathogenesis are critically considered, with particular reference to the paediatric population.