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Canadian Journal of Gastroenterology
Volume 13 (1999), Issue 9, Pages 767-770
http://dx.doi.org/10.1155/1999/810264
Case Report

Primary Biliary Cirrhosis and Type II Autoimmune Polyglandular Syndrome

Mark Ram Borgaonkar and David Geoffrey Morgan

Department of Medicine, Division of Gastroenterology, McMaster University, Hamilton, Ontario, Canada

Received 12 October 1998; Accepted 21 December 1998

Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A 45-year-old female was diagnosed with Hashimoto’s thyroiditis in 1976 and Addison’s disease in 1979. At that time, her antimitochondrial antibody (AMA) level was elevated at 1:32. She subsequently developed premature ovarian failure and type I diabetes mellitus. In 1996, she became jaundiced with a cholestatic enzyme pattern. AMA was positive at a titre of 1:256. A liver biopsy confirmed the diagnosis of primary biliary cirrhosis (PBC). She underwent a liver transplantation in January 1998. This is the first report of PBC in association with type II autoimmune polyglandular syndrome. The association of PBC with other organ-specific autoimmune diseases supports an immune-mediated pathogenesis and may have implications in further studies of PBC.