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Canadian Journal of Gastroenterology
Volume 14 (2000), Issue 2, Pages 99-110

Applications of Recombinant DNA Technology in Gastrointestinal Medicine and Hepatology: Basic Paradigms of Molecular Cell Biology. Part A: Eukaryotic Gene Structure and DNA Replication

Gary E Wild,1 Patrizia Papalia,1 Mark J Ropeleski,1 Julio Faria,1 and Alan BR Thomson2

1Department of Medicine, Division of Gastroenterology, McGill University Health Centre, and McGill University Inflammatory Bowel Disease Research Program, Montreal, Quebec, Canada
2Department of Medicine, Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada

Received 23 March 1999; Revised 15 July 1999

Copyright © 2000 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Progress in the basic sciences of cell and molecular biology has provided an exciting dimension that has translated into clinically relevant information in every medical subspecialty. Importantly, the application of recombinant DNA technology has played a major role in unravelling the intricacies related to the molecular pathophysiology of disease. This series of review articles constitutes a framework for the integration of the database of new information into the core knowledge base of concepts related to the pathogenesis of gastrointestinal disorders and liver disease. The goal of this series of three articles is to review the basic principles of eukaryotic gene expression. The first article examines the role of DNA in directing the flow of genetic information in eukaryotic cells.