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Canadian Journal of Gastroenterology
Volume 14, Issue 3, Pages 241-245
http://dx.doi.org/10.1155/2000/645639
Brief Communication

Gastric Carcinoid Tumours and Pernicious Anemia: Case Report and Review of the Literature

Sarah Hagarty,1 Istvan Hüttner,2 Henry Shibata,3 and Saul Katz1

1Department of Gastroenterology, McGill University Health Centre, Montreal, Quebec, Canada
2Department of Pathology, McGill University Health Centre, Montreal, Quebec, Canada
3Department of Surgery, McGill University Health Centre, Montreal, Quebec, Canada

Received 15 September 1998; Revised 9 June 1999

Copyright © 2000 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Patients with pernicious anemia are at risk of developing carcinoid tumours of the stomach. A patient with pernicious anemia and multifocal carcinoid tumours of the gastric fundus that regressed after antrectomy is presented. The frequent occurrence of gastric carcinoid tumours in patients with long-standing pernicious anemia suggests that surveillance gastroscopy and biopsies of the fundus might be indicated. Compete functional antrectomy may effectively cause these tumours to regress by removing their excessive gastrin hormonal stimulation. However, incomplete antrectomy can result in persistently elevated serum gastrin and failure of total disappearance of the carcinoid tumours.