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Canadian Journal of Gastroenterology
Volume 14, Issue 11, Pages 922-928

Peptic Disease in Elderly Patients

Neda Khaghan and Peter R Holt

Gastrointestinal Division, Department of Medicine, St Luke’s/Roosevelt Hospital Center, Columbia University, New York, New York, USA

Received 17 August 1999; Revised 7 September 1999

Copyright © 2000 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The increase in life expectancy demands that more attention be given to gastrointestinal problems, such as peptic ulcer disease, in elderly people. This review summarizes many of the physiological changes that have a role in peptic ulcer disease in elderly patients. How Helicobacter pylori infection modifies the course of peptic disease is also reviewed. The clinical presentation of peptic diseases often differs in elderly people, and atypical symptoms are common. Accurate diagnosis requires aggressive endoscopic evaluation. Treatment regimens using H2 receptor antagonists, proton pump inhibitors and regimens to eradicate H pylori may also need to be altered in elderly patients.