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Canadian Journal of Gastroenterology
Volume 14 (2000), Issue 1, Pages 57-61

Gene Therapy Applications in Gastroenterology and Hepatology

Catherine H Wu,1 Lanlan Shen,2 and George Y Wu1

1Department of Medicine, Division of Gastroenterology-Hepatology, University of Connecticut School of Medicine, Farmington, Conneticut, USA
2Shanghai Institute for Digestive Diseases, Shanghai Second Medical University, Renji Hospital, Shanghai, China

Received 16 December 1998; Revised 16 December 1998

Copyright © 2000 Hindawi Publishing Corporation. This open-access article is distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC) (, which permits reuse, distribution and reproduction of the article, provided that the original work is properly cited and the reuse is restricted to noncommercial purposes.


Advantages and disadvantages of viral vectors and nonviral vectors for gene delivery to digestive organs are reviewed. Advances in systems for the introduction of new gene expression are described, including self-deleting retroviral transfer vectors, chimeric viruses and chimeric oligonucleotides. Systems for inhibition of gene expression are discussed, including antisense oligonucleotides, ribozymes and dominant-negative genes.