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Canadian Journal of Gastroenterology
Volume 14 (2000), Suppl B, Pages 81B-82B

Fasciitis Complicating Subcutaneous Injection of Interferon Beta

Curtis L Cooper, Rachel Gerstein, and Kelly Kaita

Viral Hepatitis Investigative Unit, Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada

Received 20 May 1999; Accepted 9 June 1999

Copyright © 2000 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Data pertaining to 65 patients treated at the Health Sciences Center Hepatology Research Unit in Winnipeg, Manitoba describing local complications related to subcutaneous interferon (IFN) injection administered to treat hepatitis C virus infection are presented. Nine patients experienced local erythematous reactions at the injection region. No life-threatening complications were identified. One case of fasciitis complicating IFN injection – a complication not previously reported – was successfully managed with surgical debridement and antibiotic therapy. This case is a dramatic example of why sterile technique during infections must be adhered to.