Canadian Journal of Gastroenterology and Hepatology

Canadian Journal of Gastroenterology and Hepatology / 2003 / Article

Open Access

Volume 17 |Article ID 704035 | https://doi.org/10.1155/2003/704035

Francis Mégraud, "Helicobacter pylori Resistance to Antibiotics: Prevalence, Mechanism, Detection. What’s New?", Canadian Journal of Gastroenterology and Hepatology, vol. 17, Article ID 704035, 4 pages, 2003. https://doi.org/10.1155/2003/704035

Helicobacter pylori Resistance to Antibiotics: Prevalence, Mechanism, Detection. What’s New?

Abstract

Helicobacter pylori resistance to antibiotics is increasingly reported and may limit the efficacy of current treatment regimens. Their resistance mechanism has been found to be point mutations for all antibiotics. Macrolide resistance is the most clinically important, but can be detected efficiently by molecular methods. Metronidazole resistance has limited clinical impact but testing methods are not reliable. Seldomly found cases of resistance, such as to amoxicillin and tetracycline, have had their mechanism recently elucidated. The existance of rapid and practical methods for the detection of macrolide resistance (eg, Fluorescence Resonance Energy Transfer assay) should improve management of H pylori-positive patients in the future, by allowing an adapted first-line therapy.

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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