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Canadian Journal of Gastroenterology
Volume 18, Issue 2, Pages 101-104
Brief Communication

Disappearance of Crohn's Ulcers in the Terminal Ileum after Thalidomide Therapy

NB Hershfield

Division of Gastroenterology, Department of Medicine, The University of Calgary, Calgary, Alberta, Canada

Received 14 July 2003; Accepted 2 October 2003

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A case of intractable Crohn's disease unresponsive to all forms of therapy, including multiple operations and medication, is reported. The patient responded to thalidomide and this has resulted in the disappearance of the disease in the neoterminal ileum. Thalidomide may be a valuable treatment in intractable cases of Crohn's disease. The case is presented in a chronological fashion and endoscopic photographs documenting the disappearance of the disease are presented.