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Canadian Journal of Gastroenterology
Volume 18, Issue 3, Pages 163-167
http://dx.doi.org/10.1155/2004/350732
Original Article

Redefining Lactose as a Conditional Prebiotic

Andrew Szilagyi

McGill University School of Medicine, Division of Gastroenterology, Department of Medicine, The Sir Mortimer B, Davis—Jewish General Hospital, Montreal, Quebec, Canada

Received 24 September 2003; Accepted 4 February 2004

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [32 citations]

The following is the list of published articles that have cited the current article.

  • Darakhshan Ahmad, Samara Yesovitch, Andrew Szilagyi, Albert Cohen, Christina Vinokuroff, and Usha Nathwani, “Deadaption and readaptation with lactose, but no cross-adaptation to lactulose: A case of occult colonic bacterial adaptation,” Canadian Journal of Gastroenterology, vol. 18, no. 11, pp. 677–680, 2004. View at Publisher · View at Google Scholar
  • J.E. Wells, J.T. Yen2, and D.N. Miller, “Impact of dried skim milk in production diets on Lactobacillus and pathogenic bacterial shedding in growing-finishing swine1,” Journal of Applied Microbiology, vol. 99, no. 2, pp. 400–407, 2005. View at Publisher · View at Google Scholar
  • Sellick, Alazzouzi, Tomlinson, Schwartz Jr., Enattah, Halonen, Salo, Victorzon, Mecklin, Enholm, Rasinperä, Houlston, Robinson, Groop, Aaltonen, Järvelä, Forsblom, and Järvinen, “The C/C-13910 genotype of adult-type hypolactasia is associated with an increased risk of colorectal cancer in the Finnish population,” Gut, vol. 54, no. 5, pp. 643–647, 2005. View at Publisher · View at Google Scholar
  • Andrew Szilagyi, Paula Malolepszy, Samara Yesovitch, Usha Nathwani, Christina Vinokuroff, Albert Cohen, and Xiaoqing Xue, “Inverse Dose Effect of Pretest Dietary Lactose Intake on Breath Hydrogen Results and Symptoms in Lactase Nonpersistent Subjects,” Digestive Diseases and Sciences, vol. 50, no. 11, pp. 2178–2182, 2005. View at Publisher · View at Google Scholar
  • T. Passeron, J.-P. Lacour, E. Fontas, and J.-P. Ortonne, “Prebiotics and synbiotics: two promising approaches for the treatment of atopic dermatitis in children above 2 years,” Allergy, vol. 61, no. 4, pp. 431–437, 2006. View at Publisher · View at Google Scholar
  • Yussef Metugriachuk, Juichiro Tsuchiya, Francesco Marotta, Sam Kawakita, Ruichi Okura, Olivia Kuroi, and Emilio Minelli, “Effect of a prebiotic-enriched phytocompound in improving ovalbumin allergenicity,” Chinese Journal of Digestive Diseases, vol. 7, no. 4, pp. 206–210, 2006. View at Publisher · View at Google Scholar
  • Andrew Szilagyi, Usha Nathwani, Christina Vinokuroff, Ian Shrier, and José A. Correa, “The effect of lactose maldigestion on the relationship between dairy food intake and colorectal cancer: A systematic review,” Nutrition and Cancer, vol. 55, no. 2, pp. 141–150, 2006. View at Publisher · View at Google Scholar
  • Cherbut, “Lactose: Between intolerance and health benefits,” Sciences des Aliments, vol. 26, no. 6, pp. 493–499, 2006. View at Publisher · View at Google Scholar
  • S. Kolida, D.M. Saulnier, and G.R. Gibson, “Gastrointestinal Microflora: Probiotics,” Advances in Applied Microbiology Volume 59, vol. 59, pp. 187–219, 2006. View at Publisher · View at Google Scholar
  • T. He, M.G. Priebe, Y. Zhong, C. Huang, H.J.M. Harmsen, G.C. Raangs, J.-M. Antoine, G.W. Welling, and R.J. Vonk, “Effects of yogurt and bifidobacteria supplementation on the colonic microbiota in lactose-intolerant subjects,” Journal of Applied Microbiology, no. 0, pp. 071010063119001–???, 2007. View at Publisher · View at Google Scholar
  • Gertjan Schaafsma, “Lactose and lactose derivatives as bioactive ingredients in human nutrition,” International Dairy Journal, vol. 18, no. 5, pp. 458–465, 2008. View at Publisher · View at Google Scholar
  • Delphine M. Saulnier, Sofia Kolida, and Glenn R. Gibson, “Microbiology of the human intestinal tract and approaches for its dietary modulation,” Current Pharmaceutical Design, vol. 15, no. 13, pp. 1403–1414, 2009. View at Publisher · View at Google Scholar
  • Aaron Gosling, Geoff W. Stevens, Andrew R. Barber, Sandra E. Kentish, and Sally L. Gras, “Recent advances refining galactooligosaccharide production from lactose,” Food Chemistry, vol. 121, no. 2, pp. 307–318, 2010. View at Publisher · View at Google Scholar
  • Andrew Szilagyi, “Determinants of geographic patterns of diseases: Interaction of lactose/lactase status and sunshine exposure,” Medical Hypotheses, vol. 75, no. 5, pp. 466–470, 2010. View at Publisher · View at Google Scholar
  • Richard G McGee, Anouk Bakens, Kerrie Wiley, Stephen M Riordan, and Angela C WebsterCochrane Database of Systematic Reviews, 2011. View at Publisher · View at Google Scholar
  • H. Tran, R. Moreno, E. E. Hinkle, J. W. Bundy, J. Walter, T. E. Burkey, and P. S. Miller, “Effects of lactose and yeast-dried milk on growth performance, fecal microbiota, and immune parameters of nursery pigs1,” Journal of Animal Science, vol. 90, no. 9, pp. 3049–3059, 2012. View at Publisher · View at Google Scholar
  • Girardet, Fournier, Beck, Kempf, Bakhache, and Lachambre, “Tolerance and adequacy of a 100% lactose infant formula. A controlled randomized double-blind study,” Archives de Pediatrie, vol. 19, no. 7, pp. 693–699, 2012. View at Publisher · View at Google Scholar
  • Ruggiero Francavilla, Maria Calasso, Laura Calace, Sonya Siragusa, Maurice Ndagijimana, Pamela Vernocchi, Luigia Brunetti, Giuseppe Mancino, Giuseppe Tedeschi, Elisabetta Guerzoni, Flavia Indrio, Luca Laghi, Vito L. Miniello, Marco Gobbetti, and Maria De Angelis, “Effect of lactose on gut microbiota and metabolome of infants with cow’s milk allergy,” Pediatric Allergy and Immunology, vol. 23, no. 5, pp. 420–427, 2012. View at Publisher · View at Google Scholar
  • H. Tran, R. Moreno, E. E. Hinkle, J. W. Bundy, J. Walter, T. E. Burkey, and P. S. Miller, “Effect of corn distillers dried grains with solubles on growth performance and health status indicators in weanling pigs1,” Journal of Animal Science, vol. 90, no. 3, pp. 790–801, 2012. View at Publisher · View at Google Scholar
  • Hae-Soo Kwak, Won-Jae Lee, and Mee-Ryung Lee, “Revisiting lactose as an enhancer of calcium absorption,” International Dairy Journal, vol. 22, no. 2, pp. 147–151, 2012. View at Publisher · View at Google Scholar
  • Koen Venema, “Intestinal fermentation of lactose and prebiotic lactose derivatives, including human milk oligosaccharides,” International Dairy Journal, vol. 22, no. 2, pp. 123–140, 2012. View at Publisher · View at Google Scholar
  • E. Blanchard, P. Zhu, and P. Schuck, “Infant formula powders,” Handbook of Food Powders, pp. 465–483, 2013. View at Publisher · View at Google Scholar
  • Harri A. MÄKivuokko, Markku T. Saarinen, Arthur C. Ouwehand, and Nina E. Rautonen, “Effects of Lactose on Colon Microbial Community Structure and Function in a Four-Stage Semi-Continuous Culture System,” Bioscience, Biotechnology, and Biochemistry, vol. 70, no. 9, pp. 2056–2063, 2014. View at Publisher · View at Google Scholar
  • Andrew Szilagyi, “Adaptation to Lactose in Lactase Non Persistent People: Effects on Intolerance and the Relationship between Dairy Food Consumption and Evalution of Di,” Nutrients, vol. 7, no. 8, pp. 6751–6779, 2015. View at Publisher · View at Google Scholar
  • Fazheng Ren, Yuhan Wang, Songping Wang, Jie Luo, and Haixin Peng, “Progress in infant formula milk powder,” Nongye Jixie Xuebao/Transactions of the Chinese Society for Agricultural Machinery, vol. 46, no. 4, pp. 200–210, 2015. View at Publisher · View at Google Scholar
  • György Miklós Buzás, “Lactose intolerance: Past and present. Part II,” Orvosi Hetilap, vol. 156, no. 43, pp. 1741–1749, 2015. View at Publisher · View at Google Scholar
  • Tanya F. Gressley, “Bioactive Agents of Milk/Dairy Products,” Encyclopedia of Biotechnology in Agriculture and Food, pp. 1–3, 2016. View at Publisher · View at Google Scholar
  • Xiao Yan Chen, and Michael G. Gänzle, “Lactose and lactose-derived oligosaccharides: More than prebiotics?,” International Dairy Journal, vol. 67, pp. 61–72, 2017. View at Publisher · View at Google Scholar
  • Marette André, Picard-Deland Éliane, and Fernandez Melissa Anne, “8 Yogurt and Gut Health,” Yogurt: Roles in Nutrition and Impacts on Health, pp. 113–138, 2017. View at Publisher · View at Google Scholar
  • Janina A. Krumbeck, Heather E. Rasmussen, Robert W. Hutkins, Jennifer Clarke, Krista Shawron, Ali Keshavarzian, and Jens Walter, “Probiotic Bifidobacterium strains and galactooligosaccharides improve intestinal barrier function in obese adults but show no synergism when used together as synbiotics,” Microbiome, vol. 6, no. 1, 2018. View at Publisher · View at Google Scholar
  • Lee Call, Barbara Stoll, Berthe Oosterloo, Nadim Ajami, Fariha Sheikh, Anja Wittke, Rosaline Waworuntu, Brian Berg, Joseph Petrosino, Oluyinka Olutoye, and Douglas Burrin, “Metabolomic signatures distinguish the impact of formula carbohydrates on disease outcome in a preterm piglet model of NEC,” Microbiome, vol. 6, no. 1, 2018. View at Publisher · View at Google Scholar
  • Monica Grandi, Carlo Pinna, Alessio Bonaldo, Claudio Stefanelli, Carla Giuditta Vecchiato, Giuliano Zaghini, and Giacomo Biagi, “Effects of dietary supplementation with increasing doses of lactose on faecal bacterial populations and metabolites and apparent total tract digestibility in adult dogs,” Italian Journal of Animal Science, pp. 1–9, 2018. View at Publisher · View at Google Scholar