Table of Contents Author Guidelines Submit a Manuscript
Canadian Journal of Gastroenterology
Volume 18 (2004), Issue 6, Pages 397-399
http://dx.doi.org/10.1155/2004/360537
Brief Communication

Injection of Botulinum Toxin a to Upper Esophageal Sphincter for Oropharyngeal Dysphagia in Two Patients with Inclusion Body Myositis

Louis WC Liu,1,3 Mark Tarnopolsky,2,3,4 and David Armstrong1,3

1Hamilton Health Sciences, Division of Gastroenterology, McMaster University Medical Centre, Hamilton, Ontario, Canada
2Division of Neurology and Rehabilitation, McMaster University Medical Centre, Hamilton, Ontario, Canada
3Department of Medicine, McMaster University Medical Centre, Hamilton, Ontario, Canada
4Department of Pediatrics, McMaster University Medical Centre, Hamilton, Ontario, Canada

Received 2 January 2004; Accepted 5 April 2004

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Inclusion body myositis (IBM) is a progressive degenerative skeletal muscle disease leading to weakening and atrophy of both proximal and distal muscles. Dysphagia is reported in up to 86% of IBM patients. Surgical cricopharyngeal myotomy may be effective for cricopharyngeal dysphagia and there is one published report that botulinum toxin A, injected into the cricopharyngeus muscle using a hypopharyngoscope under general anesthesia, relieved IBM-associated dysphagia. This report presents the first documentation of botulinum toxin A injection into the upper esophageal sphincter using a flexible esophagogastroduodenoscope under conscious sedation, to reduce upper esophageal sphincter pressure and successfully alleviate oropharyngeal dysphagia in two IBM patients.