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Canadian Journal of Gastroenterology
Volume 18 (2004), Issue 2, Pages 136-137
Canadian Gastroenterology Elsewhere

Toward a Better Understanding of the Role of Helicobacter pylori Infection as a Cause of Dyspepsia

Frank YH Lin and Philip M Sherman

Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The relationship between gastric inflammation caused by Helicobacter pylori infection and symptoms of dyspepsia remains controversial (1). Using a murine model of gastric infection, Bercik et al provide new insights into the mechanism underlying such interactions. Gastric sections from Balb/c mice infected with H pylori, strain SS-1, were used for both histological evaluation and studies of neuromuscular physiology. Acute infection (two weeks) caused an antral-predominant polymorphonuclear cell infiltrate that was superceded by a corpus-predominant mononuclear and macrophage infiltrate in chronic infection (three to 16 months).