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Canadian Journal of Gastroenterology
Volume 19, Issue 7, Pages 415-420
Helicobacter Pylori Consensus Update 2004

Modulation of Host Cell Signal Transduction Pathways by Helicobacter Pylori Infection

Peter JM Ceponis1,3 and Nicola L Jones2,3

1Departments of Laboratory Medicine & Pathobiology, University of Toronto, Canada
2Department of Paediatrics, University of Toronto, Canada
3Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada

Copyright © 2005 Canadian Association of Gastroenterology. This open-access article is distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC) (, which permits reuse, distribution, and reproduction of the article, provided that the original work is properly cited and the reuse is restricted to noncommercial purposes.


Bacterial pathogens modulate host cell signal transduction responses to establish infection and cause disease. The purpose of the present summary, first presented at the Canadian Helicobacter Study Group meeting, is to discuss current knowledge of specific Helicobacter pylori factors, including the vacuolating cytotoxin, cytotoxin-associated gene A and the type four secretion system encoded by the cytotoxin-associated gene pathogenicity island and review the host cell signal transduction cascades that they modulate.