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Canadian Journal of Gastroenterology
Volume 19, Issue 4, Pages 257-259
Brief Communication

Angiosarcoma of the Gallbladder: Case Report and Review of the Literature

Alexandre N Odashiro,1 Patricia Rusa Pereira,1 Luciana N Odashiro Miiji,1 and Gia-Khanh Nguyen2

1Lac Laboratorio de Anatomia Patologica e Citopatologia, Campo Grande, Mato Grosso do Sul, Brazil
2Department of Laboratory Medicine and Pathology, University of Alberta Hospital, Edmonton, Alberta, Canada

Copyright © 2005 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A 62-year-old white woman with an unremarkable past medical history presented with acute cholecystitis. A cholecystectomy was performed, revealing an acute hemorrhagic and chronic cholecystitis associated with cholelithiasis. Two months after the operation, the patient developed a massive hemoperitoneum and died by hypo-volemic shock. At autopsy, an angiosarcoma measuring 5 cm in diameter was found in the liver, at the site of the gallbladder fossa. There were multiple hepatic, splenic, ovarian and peritoneal metastases and a massive hemoperitoneum consisting of 8 L of blood and blood clots. Review of the tissue sections from the patient's gallbladder confirmed the presence of an acute hemorrhagic and chronic cholecystitis and also revealed residual foci of an angiosarcoma. A review of eight previously reported cases of gallbladder angiosarcoma is also presented.