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Canadian Journal of Gastroenterology
Volume 21, Issue 3, Pages 185-188
Brief Communication

A Definitive Diagnosis of Primary Hodgkin Lymphoma on Endoscopic Biopsy Material Utilizing in-Depth Immunohistochemical Analysis

Garnet Horne,1 Shaun AC Medlicott,1 Adnan Mansoor,1 Johan Lategan,2 Raymond Lai,3 and P Beck2

1Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Canada
2Department of Internal Medicine, Peter Lougheed Centre, University of Calgary, Calgary, Canada
3Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada

Received 8 February 2006; Accepted 5 March 2006

Copyright © 2007 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The esophagus and stomach can be primary sites for Hodgkin lymphoma (HL). The pathognomonic feature of HL is the Reed-Sternberg cell. Because these cells can be rare in HL tumours, biopsies obtained via endoscopy are usually inadequate for establishing a definitive diagnosis. A case of a gastroesophageal junction primary HL is presented that was diagnosed on endoscopic biopsy material with the assistance of the immunohistochemical stains PAX5 and MUM1 which verified the presence of Reed-Sternberg cells. The patient was effectively treated for HL and avoided traditional laparotomy or thoracotomy procedures to obtain the diagnosis. This advanced immunohistochemical approach should be the standard in the diagnosis of primary gastrointestinal HL. An endoscopy-based approach should obviate more invasive, open biopsy procedures for establishing HL diagnosis.