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Canadian Journal of Gastroenterology
Volume 21, Issue 11, Pages 732-736
http://dx.doi.org/10.1155/2007/720205
Original Article

Effect of a Fermented Milk Combining Lactobacillus Acidophilus CL1285 and Lactobacillus Casei in the Prevention of Antibiotic-Associated Diarrhea: A Randomized, Double-Blind, Placebo-Controlled Trial

Mélanie Beausoleil,1 Nadia Fortier,1 Stéphanie Guénette,1 Amélie L’Ecuyer,1 Michel Savoie,1 Martin Franco,1 Jean Lachaîne,2 and Karl Weiss3

1Department of Pharmacy, Maisonneuve-Rosemont Hospital, Canada
2Department of Clinical research, University of Montreal, Canada
3Department of Microbiology and Infectious diseases, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada

Received 16 January 2007; Accepted 2 March 2007

Copyright © 2007 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [103 citations]

The following is the list of published articles that have cited the current article.

  • N. Safdar, R. Barigala, A. Said, and L. McKinley, “Feasibility and tolerability of probiotics for prevention of antibiotic-associated diarrhoea in hospitalized US military veterans,” Journal of Clinical Pharmacy and Therapeutics, vol. 33, no. 6, pp. 663–668, 2008. View at Publisher · View at Google Scholar
  • Mathieu Millette, Francois-Marie Luquet, Marcia Teresa Ruiz, Monique Lacroix, Mathieu Millette, Francois-Marie Luquet, Marcia Teresa Ruiz, and Monique Lacroix, “Characterization of probiotic properties of Lactobacillus strains,” Dairy Science & Technology, vol. 88, no. 6, pp. 695–705, 2008. View at Publisher · View at Google Scholar
  • Lynne V McFarland, “Antibiotic-associated diarrhea: epidemiology, trends and treatment,” Future Microbiology, vol. 3, no. 5, pp. 563–578, 2008. View at Publisher · View at Google Scholar
  • M. Carlsson, Y. Gustafson, L. Haglin, S. Eriksson, M. Carlsson, Y. Gustafson, L. Haglin, and S. Eriksson, “The feasibility of serving liquid yoghurt supplemented with probiotic bacteria, Lactobacillus rhamnosus LB 21, and Lactococcus lactis L1A-A pilot stud,” Journal Of Nutrition Health & Aging, vol. 13, no. 9, pp. 813–819, 2009. View at Publisher · View at Google Scholar
  • M. Carlsson, Y. Gustafson, L. Haglin, and S. Eriksson, “The feasibility of serving liquid yoghurt supplemented with probiotic bacteria, lactobacillus rhamnosus LB 21, and lactococcus lactis L1A — A pilot study among old people with dementia in a residential care facility,” The Journal of Nutrition, Health and Aging, 2009. View at Publisher · View at Google Scholar
  • Mu-Jun Xiong, Xu-Mei Jiao, Xue-Ya Luo, Bin Liu, and Cheng Zhang, “Spent culture supernatant of Lactobacillus acidophilus influences contraction of isolated intestinal smooth muscle of rabbits,” Academic Journal of Second Military Medical University, vol. 30, no. 6, pp. 690–693, 2009. View at Publisher · View at Google Scholar
  • Ronald L. Koretz, and Ronald L. Koretz, “Probiotics, Critical Illness, and Methodologic Bias,” Nutrition In Clinical Practice, vol. 24, no. 1, pp. 45–49, 2009. View at Publisher · View at Google Scholar
  • Liu, Xin Zhao, and Eveline M. Ibeagha-Awemupp. 235–250, 2009. View at Publisher · View at Google Scholar
  • E. Weichselbaum, “Probiotics and health: a review of the evidence,” Nutrition Bulletin, vol. 34, no. 4, pp. 340–373, 2009. View at Publisher · View at Google Scholar
  • Jonathan D. N. Lewis, Linda V. Thomas, William Weir, Jonathan D. N. Lewis, Linda V. Thomas, and William Weir, “The potential of probiotic fermented milk products in reducing risk of antibiotic-associated diarrhoea and Clostridium difficile disease,” International Journal Of Dairy Technology, vol. 62, no. 4, pp. 461–471, 2009. View at Publisher · View at Google Scholar
  • Hannah Claire Baker, Dang Ngoc Tran, and Linda Valerie Thomas, “Health benefits of probiotics for the elderly: a review,” Journal of Foodservice, vol. 20, no. 5, pp. 250–262, 2009. View at Publisher · View at Google Scholar
  • Christina M. Surawicz, “Probiotics and Antibiotic-Associated Diarrhea and Clostridium difficile Infection,” Prebiotics and Probiotics Science and Technology, pp. 825–843, 2009. View at Publisher · View at Google Scholar
  • Lynne V. McFarland, “Unraveling the causes of negative studies: A case of S boulardii for the prevention of antibiotic-associated diarrhea,” Revista Medica de Chile, vol. 137, no. 5, pp. 719–720, 2009. View at Publisher · View at Google Scholar
  • Mario Guslandi, “Probiotics for Antibiotic-Associated Diarrhea and Clostridium Difficile-Associated Disease,” Nutritional Management of Digestive Disorders, pp. 149–157, 2010. View at Publisher · View at Google Scholar
  • Lee Helliwell, Catherine Jackson, Lee Helliwell, and Catherine Jackson, “Probiotics: Do They Reduce The Incidence Of Antibiotic-Associated Diarrhoea In Adults?,” Emergency Medicine Journal, vol. 27, no. 4, pp. 308–308, 2010. View at Publisher · View at Google Scholar
  • Seppo Salminen, Reetta Satokari, Riikka Rantanen, and Kaisu Pitkälä, “Probiotics and Prebiotics in Elderly Individuals,” Handbook of Prebiotics and Probiotics Ingredients, 2010. View at Publisher · View at Google Scholar
  • Pramodini B Kale-Pradhan, Harjot K Jassal, and Sheila M Wilhelm, “ Role of Lactobacillus in the Prevention of Antibiotic-Associated Diarrhea: A Meta-analysis ,” Pharmacotherapy, vol. 30, no. 2, pp. 119–126, 2010. View at Publisher · View at Google Scholar
  • Joe Dylewski, Eliofotisti Psaradellis, John Sampalis, Joe Dylewski, Eliofotisti Psaradellis, and John Sampalis, “Efficacy of BIO K+CL1285 (R) in the reduction of antibiotic-associated diarrhea a placebo controlled double-blind randomized, multi-center study,” Archives Of Medical Science, vol. 6, no. 1, pp. 56–64, 2010. View at Publisher · View at Google Scholar
  • Hyun Joo Song, Jin-Yong Kim, Sung-Ae Jung, Seong-Eun Kim, Hye-Sook Park, Yoolwon Jeong, Sung Pil Hong, Jae Hee Cheon, Won Ho Kim, Hyo-Jong Kim, Byong Duk Ye, Suk-Kyun Yang, Sang-Woo Kim, Sung-Jae Shin, Hyun-Soo Kim, Jae-Kyu Sung, Eun Young Kim, Hyun Joo Song, Jin-Yong Kim, Sung-Ae Jung, Seong-Eun Kim, Hye-Sook Park, Yoolwon Jeong, Sung Pil Hong, Jae Hee Cheon, Won Ho Kim, Hyo-Jong Kim, Byong Duk Ye, Suk-Kyun Yang, Sang-Woo Kim, Sung-Jae Shin, Hyun-Soo Kim, Jae-Kyu Sung, and Eun Young Kim, “Effect of Probiotic Lactobacillus (Lacidofil (R) Cap) for the Prevention of Antibiotic-associated Diarrhea: A Prospective, Randomized, Double-blind, M,” Journal Of Korean Medical Science, vol. 25, no. 12, pp. 1784–1791, 2010. View at Publisher · View at Google Scholar
  • Iannitti, and Palmieri, “Therapeutical use of probiotic formulations in clinical practice,” Clinical Nutrition, vol. 29, no. 6, pp. 701–725, 2010. View at Publisher · View at Google Scholar
  • Barbara Karska-Wysocki, Mari Bazo, Wanda Smoragiewicz, Barbara Karska-Wysocki, Mari Bazo, and Wanda Smoragiewicz, “Antibacterial activity of Lactobacillus acidophilus and Lactobacillus casei against methicillin-resistant Staphylococcus aureus (MRSA),” Microbiological Research, vol. 165, no. 8, pp. 674–686, 2010. View at Publisher · View at Google Scholar
  • Cindy Baldwin, Mathieu Millette, Daniel Oth, Marcia T. Ruiz, Francois-Marie Luquet, Monique Lacroix, Cindy Baldwin, Mathieu Millette, Daniel Oth, Marcia T. Ruiz, Francois-Marie Luquet, and Monique Lacroix, “Probiotic Lactobacillus Acidophilus and L. Casei Mix Sensitize Colorectal Tumoral Cells to 5-Fluorouracil-Induced Apoptosis,” Nutrition And Cancer-An International Journal, vol. 62, no. 3, pp. 371–378, 2010. View at Publisher · View at Google Scholar
  • István Siró, “Challenges of Beneficial Health Claims,” Probiotics, vol. 21, pp. 243–268, 2011. View at Publisher · View at Google Scholar
  • Paolo Aureli, Lucio Capurso, Anna Maria Castellazzi, Mario Clerici, Marcello Giovannini, Lorenzo Morelli, Andrea Poli, Fabrizio Pregliasco, Filippo Salvini, Gian Vincenzo Zuccotti, Paolo Aureli, Lucio Capurso, Anna Maria Castellazzi, Mario Clerici, Marcello Giovannini, Lorenzo Morelli, Andrea Poli, Fabrizio Pregliasco, Filippo Salvini, and Gian Vincenzo Zuccotti, “Probiotics and health: An evidence-based review,” Pharmacological Research, vol. 63, no. 5, pp. 366–376, 2011. View at Publisher · View at Google Scholar
  • Mathieu Millette, Eric Simard, Serge Carriere, Mathieu Millette, Eric Simard, and Serge Carriere, “Prevention of Clostridium difficile Infections: Efficacious and High-Quality Probiotics Can Produce the Expected Effect When Used Appropriately,” American Journal Of Gastroenterology, vol. 106, no. 4, pp. 804–804, 2011. View at Publisher · View at Google Scholar
  • Peter van Baarlen, Freddy Troost, Cindy van der Meer, Guido Hooiveld, Mark Boekschoten, Robert J. M. Brummer, Michiel Kleerebezem, Peter van Baarlen, Freddy Troost, Cindy van der Meer, Guido Hooiveld, Mark Boekschoten, Robert J. M. Brummer, and Michiel Kleerebezem, “Human mucosal in vivo transcriptome responses to three lactobacilli indicate how probiotics may modulate human cellular pathways,” Proceedings Of The National Academy Of Sciences Of The United States Of America, vol. 108, pp. 4562–4569, 2011. View at Publisher · View at Google Scholar
  • Mary Hickson, “ Probiotics in the prevention of antibiotic-associated diarrhoea and Clostridium difficile infection ,” Therapeutic Advances in Gastroenterology, vol. 4, no. 3, pp. 185–197, 2011. View at Publisher · View at Google Scholar
  • Alvine Adrienne Kamdeu Fansi, Jason Robert Guertin, and Jacques LeLorier, “Savings from the use of a probiotic formula in the prophylaxis of antibiotic-associated diarrhea,” Journal of Medical Economics, vol. 15, no. 1, pp. 53–60, 2011. View at Publisher · View at Google Scholar
  • Mohamed H. Abd El-Salam, Arnold R. Hippen, Kawther El-Shafie, Faiza M. Assem, Hyam Abbas, Mahmoud Abd El-Aziz, Osama Sharaf, Mostafa El-Aassar, Kawther El-Shafie, Faiza M. Assem, Hyam Abbas, Mahmoud Abd El-Aziz, Osama Sharaf, Mostafa El-Aassar, Mohamed H. Abd El-Salam, and Arnold R. Hippen, “Preparation and properties of probiotic concentrated yoghurt (labneh) fortified with conjugated linoleic acid,” International Journal Of Food Science And Technology, vol. 46, no. 10, pp. 2103–2110, 2011. View at Publisher · View at Google Scholar
  • Bradley C. Johnston, Joshua Z. Goldenberg, Per O. Vandvik, Xin Sun, Gordon H. Guyatt, Bradley C. Johnston, Joshua Z. Goldenberg, Per O. Vandvik, Xin Sun, and Gordon H. Guyatt, “Probiotics for the prevention of pediatric antibiotic-associated diarrhea,” Cochrane Database Of Systematic Reviews, no. 11, 2011. View at Publisher · View at Google Scholar
  • Francisco Guarner, Aamir G. Khan, James Garisch, Rami Eliakim, Alfred Gangl, Alan Thomson, Justus Krabshuis, Ton Lemair, Pedro Kaufmann, Juan Andres de Paula, Richard Fedorak, Fergus Shanahan, Mary Ellen Sanders, Hania Szajewska, Balakrishnan Siddartha Ramakrishna, Tarkan Karakan, Nayoung Kim, Francisco Guarner, Aamir G. Khan, James Garisch, Rami Eliakim, Alfred Gangl, Alan Thomson, Justus Krabshuis, Ton Lemair, Pedro Kaufmann, Juan Andres de Paula, Richard Fedorak, Fergus Shanahan, Mary Ellen Sanders, Hania Szajewska, Balakrishnan Siddartha Ramakrishna, Tarkan Karakan, and Nayoung Kim, “World Gastroenterology Organisation Global Guidelines Probiotics and Prebiotics October 2011,” Journal Of Clinical Gastroenterology, vol. 46, no. 6, pp. 468–481, 2012. View at Publisher · View at Google Scholar
  • E. J. Videlock, F. Cremonini, E. J. Videlock, and F. Cremonini, “Meta-analysis: probiotics in antibiotic-associated diarrhoea,” Alimentary Pharmacology & Therapeutics, vol. 35, no. 12, pp. 1355–1369, 2012. View at Publisher · View at Google Scholar
  • Alicia R. Maher, Zhen Wang, Jeremy N. V. Miles, Roberta Shanman, Breanne Johnsen, Paul G. Shekelle, Susanne Hempel, Sydne J. Newberry, Susanne Hempel, Sydne J. Newberry, Alicia R. Maher, Zhen Wang, Jeremy N. V. Miles, Roberta Shanman, Breanne Johnsen, and Paul G. Shekelle, “Probiotics for the Prevention and Treatment of Antibiotic-Associated Diarrhea A Systematic Review and Meta-analysis,” Jama-Journal Of The American Medical Association, vol. 307, no. 18, pp. 1959–1969, 2012. View at Publisher · View at Google Scholar
  • G. Malaguarnera, F. Leggio, M. Vacante, M. Motta, M. Giordano, A. Biondi, F. Basile, S. Mastrojeni, A. Mistretta, M. Malaguarnera, M. A. Toscano, M. Salmeri, G. Malaguarnera, F. Leggio, M. Vacante, M. Motta, M. Giordano, A. Biondi, F. Basile, S. Mastrojeni, A. Mistretta, M. Malaguarnera, M. A. Toscano, and M. Salmeri, “Probiotics in the gastrointestinal diseases of the elderly,” Journal Of Nutrition Health & Aging, vol. 16, no. 4, pp. 402–410, 2012. View at Publisher · View at Google Scholar
  • Gerald Friedman, and Gerald Friedman, “The Role of Probiotics in the Prevention and Treatment of Antibiotic-Associated Diarrhea and Clostridium Difficile Colitis,” Gastroenterology Clinics Of North America, vol. 41, no. 4, pp. 763–+, 2012. View at Publisher · View at Google Scholar
  • R. Tabasco, M. Velasco, A. Delgado-Iribarren, C. Guijarro, J. Valverde, J. Fontecha, C. Pelaez, T. Requena, R. Tabasco, M. Velasco, A. Delgado-Iribarren, C. Guijarro, J. Valverde, J. Fontecha, C. Pelaez, and T. Requena, “Effects on intestinal microbiota of probiotic fermented milk used for prevention of antibiotic-associated diarrhoea,” European Food Research And Technology, vol. 235, no. 6, pp. 1199–1206, 2012. View at Publisher · View at Google Scholar
  • Elaine O. Petrof, Rupinder Dhaliwal, William Manzanares, Jennie Johnstone, Deborah Cook, Daren K. Heyland, Elaine O. Petrof, Rupinder Dhaliwal, William Manzanares, Jennie Johnstone, Deborah Cook, and Daren K. Heyland, “Probiotics in the critically ill: A systematic review of the randomized trial evidence,” Critical Care Medicine, vol. 40, no. 12, pp. 3290–3302, 2012. View at Publisher · View at Google Scholar
  • Bradley C. Johnston, Stephanie S. Y. Ma, Joshua Z. Goldenberg, Kristian Thorlund, Per O. Vandvik, Mark Loeb, Gordon H. Guyatt, Bradley C. Johnston, Stephanie S. Y. Ma, Joshua Z. Goldenberg, Kristian Thorlund, Per O. Vandvik, Mark Loeb, and Gordon H. Guyatt, “Probiotics for the Prevention of Clostridium difficile-Associated Diarrhea A Systematic Review and Meta-analysis,” Annals Of Internal Medicine, vol. 157, no. 12, pp. 878–U225, 2012. View at Publisher · View at Google Scholar
  • William Trick, Curtis Donskey, Brian Currie, Donald E. Low, Ellie J. C. Goldstein, Stuart Johnson, Pierre-Jean Maziade, Lynne V. McFarland, Stuart Johnson, Pierre-Jean Maziade, Lynne V. McFarland, William Trick, Curtis Donskey, Brian Currie, Donald E. Low, and Ellie J. C. Goldstein, “Is primary prevention of Clostridium difficile infection possible with specific probiotics?,” International Journal Of Infectious Diseases, vol. 16, no. 11, pp. E786–E792, 2012. View at Publisher · View at Google Scholar
  • Katerina Kotzampassi, Evangelos J. Giamarellos-Bourboulis, Katerina Kotzampassi, and Evangelos J. Giamarellos-Bourboulis, “Probiotics for infectious diseases: more drugs, less dietary supplementation,” International Journal Of Antimicrobial Agents, vol. 40, no. 4, pp. 288–296, 2012. View at Publisher · View at Google Scholar
  • F. Burghuber, C. Hoegenauer, F. Stockenhuber, C. Wenisch, K. Widhalm, W. Reinisch, A. Eser, F. Thalhammer, F. Burghuber, C. Hoegenauer, F. Stockenhuber, C. Wenisch, K. Widhalm, W. Reinisch, A. Eser, and F. Thalhammer, “Probiotics for the Prevention of Antibiotic-induced Diarrhea,” Zeitschrift Fur Gastroenterologie, vol. 50, no. 10, pp. 1089–1095, 2012. View at Publisher · View at Google Scholar
  • Martin H. Flochpp. 99–104, 2012. View at Publisher · View at Google Scholar
  • Joshua Z Goldenberg, Stephanie SY Ma, Jane D Saxton, Mark R Martzen, Per O Vandvik, Kristian Thorlund, Gordon H Guyatt, and Bradley C JohnstonCochrane Database of Systematic Reviews, 2013. View at Publisher · View at Google Scholar
  • Arthur C. Ouwehand, Sofia D. Forssten, Marta Z. Korczynska, Renate M. L. Zwijsen, Wouter H. Noordman, Mari Madetoja, Sofia D. Forssten, Marta Z. Korczynska, Renate M. L. Zwijsen, Wouter H. Noordman, Mari Madetoja, and Arthur C. Ouwehand, “Changes in satiety hormone concentrations and feed intake in rats in response to lactic acid bacteria,” Appetite, vol. 71, pp. 16–21, 2013. View at Publisher · View at Google Scholar
  • Glenn R. Gibson, Gemma E. Walton, and Jonathan R. Swannpp. 25–43, 2013. View at Publisher · View at Google Scholar
  • Stephen J. Allen, Kathie Wareham, Duolao Wang, Caroline Bradley, Hayley Hutchings, Wyn Harris, Anjan Dhar, Helga Brown, Alwyn Foden, Michael B. Gravenor, Dietrich Mack, Stephen J. Allen, Kathie Wareham, Duolao Wang, Caroline Bradley, Hayley Hutchings, Wyn Harris, Anjan Dhar, Helga Brown, Alwyn Foden, Michael B. Gravenor, and Dietrich Mack, “Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE),” Lancet, vol. 382, no. 9900, pp. 1249–1257, 2013. View at Publisher · View at Google Scholar
  • C. Winchester, N. de Wit, A. P. S. Hungin, C. Mulligan, B. Pot, P. Whorwell, L. Agreus, P. Fracasso, C. Lionis, J. Mendive, J. -M. Philippart de Foy, G. Rubin, C. Winchester, N. de Wit, A. P. S. Hungin, C. Mulligan, B. Pot, P. Whorwell, L. Agreus, P. Fracasso, C. Lionis, J. Mendive, J. -M. Philippart de Foy, and G. Rubin, “Systematic review: probiotics in the management of lower gastrointestinal symptoms in clinical practice - an evidence-based international guide,” Alimentary Pharmacology & Therapeutics, vol. 38, no. 8, pp. 864–886, 2013. View at Publisher · View at Google Scholar
  • P-J Maziade, J. A. Andriessen, P. Pereira, B. Currie, E. J. C. Goldstein, P-J Maziade, J. A. Andriessen, P. Pereira, B. Currie, and E. J. C. Goldstein, “Impact of adding prophylactic probiotics to a bundle of standard preventative measures for Clostridium difficile infections: enhanced and sustained de,” Current Medical Research And Opinion, vol. 29, no. 10, pp. 1341–1347, 2013. View at Publisher · View at Google Scholar
  • Tao Qin, Qi Ma, He Chen, Guowei Shu, Tao Qin, Qi Ma, He Chen, Guowei Shu, Tao Qin, Qi Ma, He Chen, and Guowei Shu, “Effect of four materials including trehalose, soluble starch, raffinose and galactose on survival of Lactobacillus acidophilus during freeze-drying,” Advanced Research On Structure, Materials And Engineering Ii, vol. 700, pp. 259–262, 2013. View at Publisher · View at Google Scholar
  • Luis Vitetta, Rachel Manuel, Joyce Zhou, Anthony Linnane, Sean Hall, and Samantha Coulson, “The Overarching Influence of the Gut Microbiome on End-Organ Function: The Role of Live Probiotic Cultures,” Pharmaceuticals, vol. 7, no. 12, pp. 954–989, 2014. View at Publisher · View at Google Scholar
  • Afshan Shafi, Umar Farooq, Kashif Akram, Mahgul Jaskani, Farzana Siddique, Amna Tanveer, Afshan Shafi, Umar Farooq, Kashif Akram, Mahgul Jaskani, Farzana Siddique, and Amna Tanveer, “Antidiarrheal Effect of Food Fermented by Various Strains of Lactobacillus,” Comprehensive Reviews In Food Science And Food Safety, vol. 13, no. 2, pp. 229–239, 2014. View at Publisher · View at Google Scholar
  • Christina Surawicz, and Christopher Damman, “The Role of Probiotics in Prevention and Treatment of GI Infections,” Intestinal Microbiota in Health and Disease, 2014. View at Publisher · View at Google Scholar
  • Iyad Issa, Rami Moucari, Iyad Issa, and Rami Moucari, “Probiotics for antibiotic-associated diarrhea: Do we have a verdict?,” World Journal Of Gastroenterology, vol. 20, no. 47, pp. 17788–17795, 2014. View at Publisher · View at Google Scholar
  • Afshan Shafi, Umar Farooq, Kashif Akram, Zafar Hayat, Mian Anjum Murtaza, Afshan Shafi, Umar Farooq, Kashif Akram, Zafar Hayat, and Mian Anjum Murtaza, “Prevention and Control of Diseases by Use of Pro- and Prebiotics (Synbiotics),” Food Reviews International, vol. 30, no. 4, pp. 291–316, 2014. View at Publisher · View at Google Scholar
  • Kerlynn Desrouilleres, Mathieu Millette, Khanh Dang Vu, Romain Touja, Monique Lacroix, Kerlynn Desrouilleres, Mathieu Millette, Khanh Dang Vu, Romain Touja, and Monique Lacroix, “Cancer preventive effects of a specific probiotic fermented milk containing Lactobacillus acidophilus CL1285, L. casei LBC80R and L. rhamnosus CLR2 on,” Journal Of Functional Foods, vol. 17, pp. 816–827, 2015. View at Publisher · View at Google Scholar
  • Alice Lan, Rong-Hong Hsieh, Cheng-Chih Tsai, Chun-Chih Huang, Alice Lan, Rong-Hong Hsieh, Cheng-Chih Tsai, and Chun-Chih Huang, “Effects of a probiotic preparation on the human faecal microflora and biochemical and haematological parameters,” Scienceasia, vol. 41, no. 3, pp. 155–161, 2015. View at Publisher · View at Google Scholar
  • Mattias E. Ivarsson, Jean-Christophe Leroux, Bastien Castagner, Mattias E. Ivarsson, Jean-Christophe Leroux, and Bastien Castagner, “Investigational new treatments for Clostridium difficile infection,” Drug Discovery Today, vol. 20, no. 5, pp. 602–608, 2015. View at Publisher · View at Google Scholar
  • Charlesnika T. Evans, Stuart Johnson, Charlesnika T. Evans, and Stuart Johnson, “Prevention of Clostridium difficile Infection With Probiotics,” Clinical Infectious Diseases, vol. 60, pp. S122–S128, 2015. View at Publisher · View at Google Scholar
  • Ellie J. C. Goldstein, Stuart Johnson, Pierre-Jean Maziade, Lynne V. McFarland, William Trick, Linda Dresser, Mathieu Millette, Hadi Mazloum, Donald E. Low, Ellie J. C. Goldstein, Stuart Johnson, Pierre-Jean Maziade, Lynne V. McFarland, William Trick, Linda Dresser, Mathieu Millette, Hadi Mazloum, and Donald E. Low, “Pathway to Prevention of Nosocomial Clostridium difficile Infection,” Clinical Infectious Diseases, vol. 60, pp. S148–S158, 2015. View at Publisher · View at Google Scholar
  • Rachna Patel, Herbert L. DuPont, Rachna Patel, and Herbert L. DuPont, “New Approaches for Bacteriotherapy: Prebiotics, New-Generation Probiotics, and Synbiotics,” Clinical Infectious Diseases, vol. 60, pp. S108–S121, 2015. View at Publisher · View at Google Scholar
  • Pierre-Jean Maziade, Pascale Pereira, Ellie J. C. Goldstein, Pierre-Jean Maziade, Pascale Pereira, and Ellie J. C. Goldstein, “A Decade of Experience in Primary Prevention of Clostridium difficile Infection at a Community Hospital Using the Probiotic Combination Lactobacillus ,” Clinical Infectious Diseases, vol. 60, pp. S144–S147, 2015. View at Publisher · View at Google Scholar
  • Julie Auclair, Martin Frappier, Mathieu Millette, Julie Auclair, Martin Frappier, and Mathieu Millette, “Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R, and Lactobacillus rhamnosus CLR2 (Bio-K+): Characterization, Manufacture, Mechanisms of ,” Clinical Infectious Diseases, vol. 60, pp. S135–S143, 2015. View at Publisher · View at Google Scholar
  • Lynne McFarland, “Probiotics for the Primary and Secondary Prevention of C. difficile Infections: A Meta-analysis and Systematic Review,” Antibiotics, vol. 4, no. 4, pp. 160–178, 2015. View at Publisher · View at Google Scholar
  • Danielle Barnes, Ann Ming Yeh, Danielle Barnes, and Ann Ming Yeh, “Bugs and Guts: Practical Applications of Probiotics for Gastrointestinal Disorders in Children,” Nutrition In Clinical Practice, vol. 30, no. 6, pp. 747–759, 2015. View at Publisher · View at Google Scholar
  • Stephanie N. Chilton, Jeremy P. Burton, and Gregor Reid, “Inclusion of Fermented Foods in Food Guides around the World,” Nutrients, vol. 7, no. 1, pp. 390–404, 2015. View at Publisher · View at Google Scholar
  • Xiao-Di Xu, Feng Shao, Xiao-Di Xu, and Feng Shao, “Enteral Ecoimmunonutrition Reduced Enteral Permeability and Serum Ghrelin Activity in Severe Cerebral Stroke Patients with Lung Infection,” Cell Biochemistry And Biophysics, vol. 71, no. 1, pp. 195–198, 2015. View at Publisher · View at Google Scholar
  • Joshua Z. Goldenberg, Lyubov Lytvyn, Justin Steurich, Patricia Parkin, Sanjay Mahant, Bradley C. Johnston, Joshua Z. Goldenberg, Lyubov Lytvyn, Justin Steurich, Patricia Parkin, Sanjay Mahant, and Bradley C. Johnston, “Probiotics for the prevention of pediatric antibiotic-associated diarrhea,” Cochrane Database Of Systematic Reviews, no. 12, 2015. View at Publisher · View at Google Scholar
  • Michael J. Fox, Kiran D. K. Ahuja, Iain K. Robertson, Madeleine J. Ball, Rajaraman D. Eri, Michael J. Fox, Kiran D. K. Ahuja, Iain K. Robertson, Madeleine J. Ball, and Rajaraman D. Eri, “Can probiotic yogurt prevent diarrhoea in children on antibiotics? A double-blind, randomised, placebo-controlled study,” Bmj Open, vol. 5, no. 1, 2015. View at Publisher · View at Google Scholar
  • Mariangela Rondanelli, “Review on microbiota and effectiveness of probiotics use in older,” World Journal of Clinical Cases, vol. 3, no. 2, pp. 156, 2015. View at Publisher · View at Google Scholar
  • Lynne V. McFarland, “An observation on inappropriate probiotic subgroup classifications in the meta-analysis by Lau and Chamberlain,” International Journal of General Medicine, vol. 9, pp. 333–335, 2016. View at Publisher · View at Google Scholar
  • Sadegh Jafarnejad, Sakineh Shab-Bidar, John R. Speakman, Karim Parastui, Milad Daneshi-Maskooni, and Kurosh Djafarian, “Probiotics Reduce the Risk of Antibiotic-Associated Diarrhea in Adults (18–64 Years) but Not the Elderly (>65 Years),” Nutrition in Clinical Practice, vol. 31, no. 4, pp. 502–513, 2016. View at Publisher · View at Google Scholar
  • Jenine R. Leal, Steven J. Heitman, John M. Conly, Elizabeth A. Henderson, and Braden J. Manns, “Cost-Effectiveness Analysis of the Use of Probiotics for the Prevention of Clostridium difficile–Associated Diarrhea in a Provincial Healthcare System,” Infection Control & Hospital Epidemiology, pp. 1–8, 2016. View at Publisher · View at Google Scholar
  • Jennifer K. Spinler, Caná L. Ross, and Tor C. Savidge, “Probiotics as adjunctive therapy for preventing Clostridium difficile infection – What are we waiting for?,” Anaerobe, 2016. View at Publisher · View at Google Scholar
  • Jacob E. Ollech, Nicole T. Shen, Carl V. Crawford, and Yehuda Ringel, “Use of probiotics in prevention and treatment of patients with Clostridium difficile infection,” Best Practice & Research Clinical Gastroenterology, vol. 30, no. 1, pp. 111–118, 2016. View at Publisher · View at Google Scholar
  • Christine S. M. Lau, and Ronald S. Chamberlain, “Probiotics are effective at preventing Clostridium difficile-associated diarrhea: A systematic review and meta-analysis,” International Journal of General Medicine, vol. 9, pp. 27–37, 2016. View at Publisher · View at Google Scholar
  • E.J.C. Goldstein, S.J. Johnson, P.-J. Maziade, C.T. Evans, J.C. Sniffen, M. Millette, and L.V. McFarland, “Probiotics and prevention of Clostridium difficile infection,” Anaerobe, 2016. View at Publisher · View at Google Scholar
  • Kassia Kiss Firmino Dourado Costa, Manoel Soares Soares Júnior, Sarah Inês Rodrigues Rosa, Márcio Caliari, and Tatiana Colombo Pimentel, “Changes of probiotic fermented drink obtained from soy and rice byproducts during cold storage,” LWT - Food Science and Technology, 2016. View at Publisher · View at Google Scholar
  • A. Sinclair, X. Xie, L. Saab, and N. Dendukuri, “Lactobacillus probiotics in the prevention of diarrhea associated with Clostridium difficile: a systematic review and Bayesian hierarchical meta-analysis,” CMAJ Open, vol. 4, no. 4, pp. E706–E718, 2016. View at Publisher · View at Google Scholar
  • Lucía Feijoo-Siota, Angeles Sánchez-Pérez, Tomás G. Villa, José Luis R. Rama, and Trinidad De Miguel-Bouzaspp. 315–352, 2016. View at Publisher · View at Google Scholar
  • Patrick Alexander Wachholz, Paulo José Fortes Villas Boas, and Vânia dos Santos Nunes, “Evidence and Rationale for Probiotics to Prevent Infections in the Elderly,” Probiotics, Prebiotics, and Synbiotics, pp. 661–667, 2016. View at Publisher · View at Google Scholar
  • Jae Hyun Shin, Esteban Chaves-Olarte, and Cirle A. Warren, “Clostridium difficile infection,” Microbiology Spectrum, vol. 4, no. 3, 2016. View at Publisher · View at Google Scholar
  • Jenna Wick, Tinzar Basein, and Shira Doron, “C. difficile Microbiome Manipulation,” Infection Prevention, pp. 153–162, 2017. View at Publisher · View at Google Scholar
  • Ravi Mallina, J. Craik, N. Briffa, Viren Ahulawalia, J. Clarke, and A.G. Cobb, “Probiotic containing Lactobacillus casei , Lactobacillus bulgaricus , and Streptococcus thermophiles (ACTIMEL) for the prevention of Clostridium difficile associated diarrhoea in the elderly with proximal femur fractures,” Journal of Infection and Public Health, 2017. View at Publisher · View at Google Scholar
  • M. Rätsep, S. Kõljalg, E. Sepp, I. Smidt, K. Truusalu, E. Songisepp, J. Stsepetova, P. Naaber, R.H. Mikelsaar, and M. Mikelsaar, “A combination of the probiotic and prebiotic product can prevent the germination of Clostridium difficile spores and infection,” Anaerobe, 2017. View at Publisher · View at Google Scholar
  • Nicole T. Shen, Anna Maw, Lyubov L. Tmanova, Alejandro Pino, Kayley Ancy, Carl V. Crawford, Matthew S. Simon, and Arthur T. Evans, “Timely Use of Probiotics in Hospitalized Adults Prevents Clostridium difficile Infection: A Systematic Review With Meta-Regression Analysis,” Gastroenterology, 2017. View at Publisher · View at Google Scholar
  • Joshua Z Goldenberg, Christina Yap, Lyubov Lytvyn, Calvin Ka-Fung Lo, Jennifer Beardsley, Dominik Mertz, and Bradley C Johnston, “Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children,” Cochrane Database of Systematic Reviews, 2017. View at Publisher · View at Google Scholar
  • G. Zoumpopoulou, E. Tsakalidou, and L.V. Thomas, “An Overview of Probiotic Research,” Probiotic Dairy Products, pp. 293–357, 2017. View at Publisher · View at Google Scholar
  • Jiayi Cai, Chunyang Zhao, Yajie Du, Yaqiong Zhang, Mingyi Zhao, and Qingchun Zhao, “Comparative efficacy and tolerability of probiotics for antibiotic-associated diarrhea: Systematic review with network meta-analysis,” United European Gastroenterology Journal, pp. 205064061773698, 2017. View at Publisher · View at Google Scholar
  • Lauren E. Hudson, Anita H. Corbett, Sarah E. Anderson, and Tracey J. Lamb, “Gleaning insights from fecal microbiota transplantation and probiotic studies for the rational design of combination microbial therapies,” Clinical Microbiology Reviews, vol. 30, no. 1, pp. 191–231, 2017. View at Publisher · View at Google Scholar
  • Christine N’tcha, Haziz Sina, Adéchola Pierre Polycarpe Kayodé, Joachim D. Gbenou, and Lamine Baba-Moussa, “Antimicrobial Activity and Chemical Composition of “Kpètè-Kpètè”: A Starter of Benin Traditional Beer Tchoukoutou,” BioMed Research International, vol. 2017, pp. 1–10, 2017. View at Publisher · View at Google Scholar
  • Mirjana Bojanić Rašović, “Potential of indigenous lactobacilli as starter culture in dairy products,” Acta Periodica Technologica, vol. 48, pp. 39–52, 2017. View at Publisher · View at Google Scholar
  • Douglas, and Voorhies, “Evidence based selection of probiotic strains to promote astronaut health or alleviate symptoms of illness on long duration spaceflight missions,” Beneficial Microbes, vol. 8, no. 5, pp. 727–737, 2017. View at Publisher · View at Google Scholar
  • K. Preston, R. Krumian, J. Hattner, D. de Montigny, M. Stewart, and S. Gaddam, “ Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R and Lactobacillus rhamnosus CLR2 improve quality-of-life and IBS symptoms: a double-blind, randomised, placebo-controlled study ,” Beneficial Microbes, vol. 9, no. 5, pp. 697–706, 2018. View at Publisher · View at Google Scholar
  • Valeria Agamennone, Cyrille A. M. Krul, Ger Rijkers, and Remco Kort, “A practical guide for probiotics applied to the case of antibiotic-associated diarrhea in The Netherlands,” BMC Gastroenterology, vol. 18, no. 1, 2018. View at Publisher · View at Google Scholar
  • Lynne V. McFarland, Charlesnika T. Evans, and Ellie J. C. Goldstein, “Strain-Specificity and Disease-Specificity of Probiotic Efficacy: A Systematic Review and Meta-Analysis,” Frontiers in Medicine, vol. 5, 2018. View at Publisher · View at Google Scholar
  • William E. Trick, Stephen J. Sokalski, Stuart Johnson, Kristen L. Bunnell, Joseph Levato, Michael J. Ray, and Robert A. Weinstein, “Effectiveness of Probiotic for Primary Prevention of Clostridium difficile Infection: A Single-Center Before-and-After Quality Improvement Intervention at a Tertiary-Care Medical Center,” Infection Control & Hospital Epidemiology, pp. 1–6, 2018. View at Publisher · View at Google Scholar
  • Lynne V. McFarland, Noam Ship, Julie Auclair, and Mathieu Millette, “Primary prevention of Clostridium difficile infections with a specific probiotic combining Lactobacillus acidophilus CL1285, L. casei LBC80R and L. rhamnosus CLR2: A critical appraisal of the evidence,” Journal of Hospital Infection, 2018. View at Publisher · View at Google Scholar
  • A. P. S. Hungin, C. R. Mitchell, P. Whorwell, C. Mulligan, O. Cole, L. Agréus, P. Fracasso, C. Lionis, J. Mendive, J.-M. Philippart de Foy, B. Seifert, K.-A. Wensaas, C. Winchester, and N. de Wit, “Systematic review: probiotics in the management of lower gastrointestinal symptoms - an updated evidence-based international consensus,” Alimentary Pharmacology & Therapeutics, 2018. View at Publisher · View at Google Scholar
  • Patrick Alexander Wachholz, Vânia dos Santos Nunes, Adriana Polachini do Valle, Alessandro Ferrari Jacinto, and Paulo José Fortes Villas-Boas, “Effectiveness of probiotics on the occurrence of infections in older people: systematic review and meta-analysis,” Age and Ageing, 2018. View at Publisher · View at Google Scholar
  • Jotham Suez, Niv Zmora, and Eran Elinav, “Probiotics in the next-generation sequencing era,” Gut Microbes, pp. 1–17, 2019. View at Publisher · View at Google Scholar
  • Qin Guo, Joshua Z Goldenberg, Claire Humphrey, Regina El Dib, and Bradley C Johnston, “Probiotics for the prevention of pediatric antibiotic-associated diarrhea,” Cochrane Database of Systematic Reviews, 2019. View at Publisher · View at Google Scholar
  • Dayong Ren, Di Wang, Hongyan Liu, Minghao Shen, and Hansong Yu, “ Two strains of probiotic Lactobacillus enhance immune response and promote naive T cell polarization to Th1 ,” Food and Agricultural Immunology, vol. 30, no. 1, pp. 281–295, 2019. View at Publisher · View at Google Scholar
  • Léa Siegwald, and Harald Brüssow, “Gut Microbiota and Healthy Aging,” Reference Module in Biomedical Sciences, 2019. View at Publisher · View at Google Scholar