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Canadian Journal of Gastroenterology
Volume 21, Issue 12, Pages 835-837
Brief Communication

Refractory Crohn’s Disease of the Vulva Treated with Infliximab: A Case Report

Sapna Makhija,1 Martin Trotter,2 Elizabeth Wagner,3 Sylvain Coderre,1 and Remo Panaccione1

1Division of Gastroenterology, University of Calgary, Calgary, Alberta, Canada
2Division of Pathology, University of Calgary, Calgary, Alberta, Canada
3Division of Obstetrics and Gynecology, University of Calgary, Calgary, Alberta, Canada

Received 4 August 2006; Accepted 30 November 2006

Copyright © 2007 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Crohn’s disease (CD) is a chronic relapsing and remitting inflammatory disorder of the gastrointestinal tract. The common presentation includes abdominal pain, abdominal cramping and diarrhea. Many patients may exhibit systemic symptoms of fever and weight loss. Approximately 20% to 40% of patients will experience extraintestinal manifestations that involve the eyes, skin and joints. Women may experience a variety of gynecological manifestations, including vulvovaginal involvement, which is often not recognized and also difficult to treat. A case of refractory vulvovaginal CD is presented and the literature of gynecological manifestations of CD and its treatment are reviewed.