Table of Contents Author Guidelines Submit a Manuscript
Canadian Journal of Gastroenterology
Volume 22, Issue 4, Pages 405-410
http://dx.doi.org/10.1155/2008/104398
Review

Endoscopic Ultrasound-Guided Intratumoural Therapy for Pancreatic Cancer

Brian M Yan1 and Jacques Van Dam2

1Division of Gastroenterology, University of Calgary, Calgary, Alberta, Canada
2Division of Gastroenterology, Department of Medicine, Stanford University Medical Center, Stanford, California, USA

Received 31 August 2007; Accepted 26 November 2007

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Pancreatic cancer is the second most frequent gastrointestinal malignancy and carries a dismal prognosis. The current standard of care includes resection, if possible, as well as systemic chemoradiation therapy. Endoscopic ultrasound (EUS) is an established technique for the diagnosis and staging of pancreatic adenocarcinoma. Interventional EUS via fine needle injection (FNI) for the treatment of pancreatic cancer is a rapidly expanding field. The present article reviews the up-to-date developments in EUS FNI for intratumoural pancreatic cancer therapy, including antitumoural agents, immunotherapy, ablative techniques and new delivery systems. The therapeutic modalities discussed are currently under development and will hopefully reach clinical practice if benefit is demonstrated through clinical trials. EUS FNI may be an exciting new technique for the delivery of desperately needed novel therapies for pancreatic cancer.