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Canadian Journal of Gastroenterology
Volume 22 (2008), Issue 2, Pages 153-154
http://dx.doi.org/10.1155/2008/127684
Original Article

Survival after Liver Transplantation for Hepatitis C Is Unchanged over Two Decades in Canada

Kymberly DS Watt,1 Kelly W Burak,2 Marc Deschênes,3 Les Lilly,4 Denis Marleau,5 Paul Marotta,6 Andrew Mason,7 Kevork M Peltekian,1 Eberhard Renner,8 Eric M Yoshida,9 and for the Canadian Transplant Hepatology Outcomes Research Network

1Division of Gastroenterology, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
2University of Calgary Liver Unit, Calgary, Alberta, Canada
3McGill University Health Centre, Montreal, Quebec, Canada
4University of Toronto, University Health Network Liver Transplant Program, Toronto, Ontario, Canada
5St. Luc Hospital, Centre Hospitalier de l’Université de Montreal, University of Montreal, Montreal, Quebec, Canada
6Division of Gastroenterology, Department of Medicine, University of Western Ontario, Liver Unit, London Health Sciences Centre, London, Ontario, Canada
7Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
8Section of Hepatology, Department of Internal Medicine, University of Manitoba, Health Sciences Centre, Winnipeg, Manitoba, Canada
9Division of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

Received 8 June 2007; Accepted 18 September 2007

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Allograft failure secondary to recurrence of hepatitis C virus (HCV) infection is the most common cause of death and retransplantation among recipients with HCV infection. It has been suggested that patients transplanted for HCV have had worse outcomes in more recent years than in previous years (the ‘era effect’). A Canadian transplantation registry database was analyzed to determine the outcomes of patients transplanted over the years for HCV. The results of the present analysis of 1002 patients show that the ‘era effect’ was not seen in liver transplantation recipients with HCV in Canada, because no survival difference was noted based on the year of transplantation. All groups had overall two-year and five-year survival rates of 76% to 83% and 69% to 72%, respectively. The present study’s national results prove continued benefit to transplantation of HCV patients.