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Canadian Journal of Gastroenterology
Volume 22, Issue 5, Pages 461-464
Original Article

S100 Calgranulin Proteins S100A8, S100A9 and S100A12 are Expressed in the Inflamed Gastric Mucosa of Helicobacter Pylori-Infected Children

Steven T Leach,1 Hazel M Mitchell,2 Carolyn L Geczy,3 Philip M Sherman,4 and Andrew S Day1,5

1School of Women’s and Children’s Health, University of New South Wales, Sydney, Australia
2School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia
3Inflammatory Diseases Research Unit, School of Medical Sciences, University of New South Wales, Sydney, Australia
4Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
5Department of Gastroenterology, Sydney Children’s Hospital Randwick, Sydney, Australia

Received 6 December 2007; Accepted 24 February 2008

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The expression of the inflammatory S100 calgranulin proteins (S100A8, S100A9 and S100A12) in normal and Helicobacter pylori-infected gastric mucosa of children were examined. S100A8, S100A9 and S100A12, which were virtually absent in normal gastric mucosa, were highly expressed in H pylori-infected mucosa. This expression correlated with the severity of gastritis (r=0.9422, P<0.05). S100 calgranulins may be involved in bacterial-induced gastritis and may limit bacterial growth.