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Canadian Journal of Gastroenterology
Volume 23, Issue 6, Pages 415-419
Brief Communication

Esophageal Papillomatosis Complicated by Squamous Cell Carcinoma

Tan Attila,1 Anna Fu,1 Nanda Gopinath,3 Catherine J Streutker,2 and Norman E Marcon1

1Division of Gastroenterology, Centre of Therapeutic Endoscopy and Endoscopic Oncology, Toronto, Ontario, Canada
2Department of Pathology, University of Toronto, St Michael’s Hospital, Toronto, Ontario, Canada
3Division of Gastroenterology, Toronto Eastern General Hospital, Toronto, Ontario, Canada

Received 11 June 2008; Accepted 12 June 2008

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Esophageal papillomatosis is a very rare condition that is believed to have a benign clinical course. Recent reports underscore the potential development of a malignancy in association with squamous papillomatosis of the esophagus. A case of esophageal papillomatosis complicated by the development of esophageal invasive squamous cell carcinoma diagnosed after esophagectomy, despite multiple nondiagnostic endoscopic biopsies, is described. The patient also developed squamous cell carcinoma in the oral cavity and pyloric channel. The finding of extensive esophageal papillomatosis and unremitting dysphagia symptoms should prompt investigations into an underlying associated malignancy.