Canadian Journal of Gastroenterology and Hepatology

Canadian Journal of Gastroenterology and Hepatology / 2009 / Article

Original Article | Open Access

Volume 23 |Article ID 693794 |

Andrew Szilagyi, Ian Shrier, George Chong, Jung Sung Je, Sunghoon Park, Debra Heilpern, Catherine Lalonde, Louis-Francois Cote, Byong Lee, "Lack of Effect of Lactose Digestion Status on Baseline Fecal Microflora", Canadian Journal of Gastroenterology and Hepatology, vol. 23, Article ID 693794, 7 pages, 2009.

Lack of Effect of Lactose Digestion Status on Baseline Fecal Microflora

Received10 Dec 2008
Accepted13 Jan 2009


BACKGROUND: The genetics of intestinal lactase divide the world’s population into two phenotypes: the ability (a dominant trait) or inability (a recessive trait) to digest lactose. A prebiotic effect of lactose may impact the colonic flora of these phenotypes differently.OBJECTIVE: To detect and evaluate the effects of lactose on subjects divided according to their ability to digest lactose.METHODS: A total of 57 healthy maldigesters (n=30) and digesters (n=27) completed diet questionnaires, genetic and breath hydrogen testing, and quantitative stool analysis for species of bacteria. Log10 transformation of bacterial counts was compared with lactose intake in both groups using multiple regression analysis.RESULTS: There was a significant relationship between genetic and breath hydrogen tests. Daily lactose intake was marginally lower in lactose maldigesters (median [interquartile range] 12.2 g [31 g] versus 15 g [29.6 g], respectively). There was no relationship between lactose intake and breath hydrogen tests in either group. There were no differences in bacterial counts between the two groups, nor was there a relationship between bacterial counts and lactose intake in either group.CONCLUSION: The differential bacterial effects of lactose were not quantitatively detected in stool samples taken in the present study.

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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