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Canadian Journal of Gastroenterology
Volume 27, Issue 5, Pages 281-285

Pathogenicity, Host Responses and Implications for Management of Enterohemorrhagic Escherichia coli O157:H7 Infection

Nathan K Ho,1,2 Aleah C Henry,3 Kathene Johnson-Henry,1 and Philip M Sherman1,2

1Department of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, Canada
2Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
3Department of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada

Received 20 July 2012; Accepted 26 November 2012

Copyright © 2013 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Enterohemorrhagic Escherichia coli serotype O157:H7 is a food- and waterborne pathogen that causes significant morbidity and mortality in both developing and industrialized nations. The present review focuses on the history, epidemiology and evolution of the pathogen; provides a mechanistic overview of major virulence factors (including Shiga toxins, locus of enterocyte effacement pathogenicity island and pO157 plasmid); discusses host immune responses to infection; considers available animal models; and provides an overview of current and potential future management considerations.