Modern Treatments and Stem Cell Therapies for Perianal Crohn’s Fistulas

Table 1

Summary of conventional and biological medical treatments of fistulizing CD and reported outcomes.

Treatment	Studies	Outcome
Antibiotics	Brandt et al. [5], Prantera et al. [6]; uncontrolled studies	Symptoms reduction but failed closure
	Thia et al. [7] an RCT; AB versus placebo.	No significant difference
Thiopurines	Pearson et al. [8] a meta-analysis; Thio versus placebo	Complete fistula closure or reduction in fistula drainage in 54% of patients
Anti-TNF alpha
Infliximab	Present study [9] 5 mg/kg versus 10 mg/kg versus placebo	≥50% closure; 68% versus 56% versus 26% (, , resp.)
	ACCENT II study [10] infliximab versus placebo	Maintenance of complete closure of draining fistula; 36% versus 19% ()
Adalimumab	CHARM study [12] adalimumab versus placebo	Complete fistula healing at 56 wks; 33% versus 13% ()
	ADHERE study [13]	23% fistula remission, 41% fistula improvement
Certolizumab pegol	Schreiber et al. [14] an RCT; certolizumab pegol versus placebo	Complete closure at 26 weeks; 36% versus 17% ()