Table of Contents Author Guidelines Submit a Manuscript
Canadian Journal of Gastroenterology and Hepatology
Volume 2016, Article ID 1980686, 9 pages
http://dx.doi.org/10.1155/2016/1980686
Research Article

Altered Esophageal Mucosal Structure in Patients with Celiac Disease

1Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada L8S 4K1
2Department of Medicine, “Dr. Carlos Bonorino Udaondo” Gastroenterology Hospital, 1264 Buenos Aires, Argentina
3Favaloro University Hospital, 1093 Buenos Aires, Argentina
4Consejo de Investigación en Salud, MSAL, Gobierno de la Ciudad Autónoma de Buenos Aires, 1425 Buenos Aires, Argentina
5Gastroenterology Chair, Universidad del Salvador, 1056 Buenos Aires, Argentina

Received 23 December 2015; Accepted 28 December 2015

Copyright © 2016 María Inés Pinto-Sánchez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Rubio-Tapia, I. D. Hill, C. P. Kelly, A. H. Calderwood, and J. A. Murray, “ACG clinical guidelines: diagnosis and management of celiac disease,” American Journal of Gastroenterology, vol. 108, no. 5, pp. 656–676, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. C. P. Kelly, J. C. Bai, E. Liu, and D. A. Leffler, “Advances in diagnosis and management of celiac disease,” Gastroenterology, vol. 148, no. 6, pp. 1175–1186, 2015. View at Publisher · View at Google Scholar
  3. P. H. R. Green and C. Cellier, “Medical progress: celiac disease,” The New England Journal of Medicine, vol. 357, no. 17, pp. 1731–1743, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. D. Schuppan, Y. Junker, and D. Barisani, “Celiac disease: from pathogenesis to novel therapies,” Gastroenterology, vol. 137, no. 6, pp. 1912–1933, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. E. Smecuol, J. C. Bai, H. Vazquez et al., “Gastrointestinal permeability in celiac disease,” Gastroenterology, vol. 112, no. 4, pp. 1129–1136, 1997. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Sapone, K. M. Lammers, V. Casolaro et al., “Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity,” BMC Medicine, vol. 9, article 23, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. N. Vakil, S. V. van Zanten, P. Kahrilas, J. Dent, R. Jones, and Global Consensus Group, “The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus,” The American Journal of Gastroenterology, vol. 101, no. 8, pp. 1900–1920, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. K. R. DeVault and D. O. Castell, “Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease,” American Journal of Gastroenterology, vol. 100, no. 1, pp. 190–200, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. G. E. Boeckxstaens and W. O. Rohof, “Pathophysiology of gastroesophageal reflux disease,” Gastroenterology Clinics of North America, vol. 43, no. 1, pp. 15–25, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. P. Woodland and D. Sifrim, “Esophageal mucosal integrity in nonerosive reflux disease,” Journal of Clinical Gastroenterology, vol. 48, no. 1, pp. 6–12, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. W. J. Barlow and R. C. Orlando, “The pathogenesis of heartburn in nonerosive reflux disease: a unifying hypothesis,” Gastroenterology, vol. 128, no. 3, pp. 771–778, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. R. Caviglia, M. Ribolsi, M. Gentile et al., “Dilated intercellular spaces and acid reflux at the distal and proximal oesophagus in patients with non-erosive gastro-oesophageal reflux disease,” Alimentary Pharmacology and Therapeutics, vol. 25, no. 5, pp. 629–636, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. N. R. Reilly, A. Fasano, and P. H. R. Green, “Presentation of celiac disease,” Gastrointestinal Endoscopy Clinics of North America, vol. 22, no. 4, pp. 613–621, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. A. J. Lucendo, “Esophageal manifestations of celiac disease,” Diseases of the Esophagus, vol. 24, no. 7, pp. 470–475, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. F. Nachman, H. Vázquez, A. González et al., “Gastroesophageal reflux symptoms in patients with celiac disease and the effects of a gluten-free diet,” Clinical Gastroenterology and Hepatology, vol. 9, no. 3, pp. 214–219, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Cuomo, M. Romano, A. Rocco, G. Budillon, C. Del Vecchio Blanco, and G. Nardone, “Reflux oesophagitis in adult coeliac disease: beneficial effect of a gluten free diet,” Gut, vol. 52, no. 4, pp. 514–517, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. R. Lamanda, A. Panarese, and S. De Stefano, “Coeliac disease and gastroesophageal non-erosive reflux: prevalence and effect of gluten free-diet,” Digestive and Liver Disease, vol. 41, supplement 1, article S90, 2009. View at Publisher · View at Google Scholar
  18. A. Tursi, “The treatment of gastro-esophageal reflux disease in adult celiac disease,” Journal of Clinical Gastroenterology, vol. 38, no. 8, pp. 724–726, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. D. A. Leffler and C. P. Kelly, “Celiac disease and gastroesophageal reflux disease: yet another presentation for a clinical chameleon,” Clinical Gastroenterology and Hepatology, vol. 9, no. 3, pp. 192–193, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. P. Usai, P. Usai Satta, M. Lai et al., “Autonomic dysfunction and upper digestive functional disorders in untreated adult coeliac disease,” European Journal of Clinical Investigation, vol. 27, no. 12, pp. 1009–1015, 1997. View at Publisher · View at Google Scholar · View at Scopus
  21. P. Iovino, C. Ciacci, F. Sabbatini, D. M. Acioli, G. D'Argenio, and G. Mazzacca, “Esophageal impairment in adult celiac disease with steatorrhea,” The American Journal of Gastroenterology, vol. 93, no. 8, pp. 1243–1249, 1998. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Öberg, J. H. Peters, T. R. DeMeester et al., “Endoscopic grading of the gastroesophageal valve in patients with symptoms of gastroesophageal reflux disease (GERD),” Surgical Endoscopy, vol. 13, no. 12, pp. 1184–1188, 1999. View at Publisher · View at Google Scholar · View at Scopus
  23. L. R. Lundell, J. Dent, J. R. Bennett et al., “Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification,” Gut, vol. 45, no. 2, pp. 172–180, 1999. View at Publisher · View at Google Scholar · View at Scopus
  24. G. Oberhuber, G. Granditsch, and H. Vogelsang, “The histopathology of coeliac disease: time for a standardized report scheme for pathologists,” European Journal of Gastroenterology and Hepatology, vol. 11, no. 10, pp. 1185–1194, 1999. View at Google Scholar · View at Scopus
  25. J. Svedlund, I. Sjödin, and G. Dotevall, “GSRS—a clinical rating scale for gastrointestinal symptoms in patients with irritable bowel syndrome and peptic ulcer disease,” Digestive Diseases and Sciences, vol. 33, no. 2, pp. 129–134, 1988. View at Publisher · View at Google Scholar · View at Scopus
  26. N. A. Tobey, J. L. Carson, R. A. Alkiek, and R. C. Orlando, “Dilated intercellular spaces: a morphological feature of acid reflux—damaged human esophageal epithelium,” Gastroenterology, vol. 111, no. 5, pp. 1200–1205, 1996. View at Publisher · View at Google Scholar · View at Scopus
  27. C. M. Niessen, “Tight junctions/adherens junctions: basic structure and function,” The Journal of Investigative Dermatology, vol. 127, no. 11, pp. 2525–2532, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. K. Mönkemüller, T. Wex, D. Kuester et al., “Role of tight junction proteins in gastroesophageal reflux disease,” BMC Gastroenterology, vol. 12, article 128, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. C. Calabrese, M. Bortolotti, A. Fabbri et al., “Reversibility of GERD ultrastructural alterations and relief of symptoms after omeprazole treatment,” American Journal of Gastroenterology, vol. 100, no. 3, pp. 537–542, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. R. Ciccocioppo, A. Finamore, C. Ara, A. Di Sabatino, E. Mengheri, and G. R. Corazza, “Altered expression, localization, and phosphorylation of epithelial junctional proteins in celiac disease,” American Journal of Clinical Pathology, vol. 125, no. 4, pp. 502–511, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. D. N. Szakál, H. Gyorffy, A. Arató et al., “Mucosal expression of claudins 2, 3 and 4 in proximal and distal part of duodenum in children with coeliac disease,” Virchows Archiv, vol. 456, no. 3, pp. 245–250, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Fasano, “Zonulin, regulation of tight junctions, and autoimmune diseases,” Annals of the New York Academy of Sciences, vol. 1258, no. 1, pp. 25–33, 2012. View at Publisher · View at Google Scholar · View at Scopus
  33. S. F. Assimakopoulus, I. Papageorgiou, and A. Charonis, “Enterocytes' tight junctions: from molecules to diseases,” World Journal of Gastroenterology, vol. 2, no. 6, pp. 123–137, 2011. View at Publisher · View at Google Scholar
  34. E. V. C. Björkman, A. Edebo, M. Oltean, and A. Casselbrant, “Esophageal barrier function and tight junction expression in healthy subjects and patients with gastroesophageal reflux disease: functionality of esophageal mucosa exposed to bile salt and trypsin in vitro,” Scandinavian Journal of Gastroenterology, vol. 48, no. 10, pp. 1118–1126, 2013. View at Publisher · View at Google Scholar · View at Scopus
  35. T. Rauhavirta, K. Lindfors, O. Koskinen et al., “Impaired epithelial integrity in the duodenal mucosa in early stages of celiac disease,” Translational Research, vol. 164, no. 3, pp. 223–231, 2014. View at Publisher · View at Google Scholar · View at Scopus
  36. G. R. Sander, A. G. Cummins, and B. C. Powell, “Rapid disruption of intestinal barrier function by gliadin involves altered expression of apical junctional proteins,” FEBS Letters, vol. 579, no. 21, pp. 4851–4855, 2005. View at Publisher · View at Google Scholar · View at Scopus
  37. T. T. Salmi, P. Collin, I. R. Korponay-Szabó et al., “Endomysial antibody-negative coeliac disease: clinical characteristics and intestinal autoantibody deposits,” Gut, vol. 55, no. 12, pp. 1746–1753, 2006. View at Publisher · View at Google Scholar · View at Scopus
  38. E. Sugai, A. Cherñavsky, S. Pedreira et al., “Bone-specific antibodies in sera from patients with celiac disease: characterization and implications in osteoporosis,” Journal of Clinical Immunology, vol. 22, no. 6, pp. 353–362, 2002. View at Publisher · View at Google Scholar · View at Scopus
  39. X. Yin, Z. Chen, Z. Liu, and C. Song, “Tissue transglutaminase (TG2) activity regulates osteoblast differentiation and mineralization in the SAOS-2 cell line,” Brazilian Journal of Medical and Biological Research, vol. 45, no. 8, pp. 693–700, 2012. View at Publisher · View at Google Scholar · View at Scopus
  40. A. J. Naiyer, J. Shah, L. Hernandez et al., “Tissue transglutaminase antibodies in individuals with celiac disease bind to thyroid follicles and extracellular matrix and may contribute to thyroid dysfunction,” Thyroid, vol. 18, no. 11, pp. 1171–1178, 2008. View at Publisher · View at Google Scholar · View at Scopus
  41. T.-F. Kuo, H. Tatsukawa, T. Matsuura, K. Nagatsuma, S. Hirose, and S. Kojima, “Free fatty acids induce transglutaminase 2-dependent apoptosis in hepatocytes via ER stress-stimulated PERK pathways,” Journal of Cellular Physiology, vol. 227, no. 3, pp. 1130–1137, 2012. View at Publisher · View at Google Scholar · View at Scopus
  42. N. J. Robinson, J. D. Glazier, S. L. Greenwood, P. N. Baker, and J. D. Aplin, “Tissue transglutaminase expression and activity in placenta,” Placenta, vol. 27, no. 2-3, pp. 148–157, 2006. View at Publisher · View at Google Scholar · View at Scopus
  43. G. Borroni, F. Biagi, O. Ciocca et al., “IgA anti-epidermal transglutaminase autoantibodies: a sensible and sensitive marker for diagnosis of dermatitis herpetiformis in adult patients,” Journal of the European Academy of Dermatology and Venereology, vol. 27, no. 7, pp. 836–841, 2013. View at Publisher · View at Google Scholar · View at Scopus