Research Article
The Utility of Endoscopic Biopsies in Patients with Normal Upper Endoscopy
Table 5
Yield of pathologic abnormality and cost per positive finding on macroscopically normal EGDs based on the clinical indication.
| | Indication | Pathologic finding | Histologic abnormality (%)
(absolute number) | Cost/positive finding ( CAD) |
| | Dysphagia | Reflux esophagitis | 25% (14/56) | 313 | | Eosinophilic esophagitis | 11% (6/56) | 711 |
| | Heartburn | Reflux esophagitis | 21% (24/113) | 372 | | Eosinophilic esophagitis | 0% (0/113) | — |
| | Dyspepsia | Reflux esophagitis | 15% (33/220) | 521 | | Chronic gastritis | 27% (140/520) | 298 | | HP gastritis | 6% (31/520) | 1404 | | Celiac disease | 2% (8/420) | 3992 |
| | Anemia | Reflux esophagitis | 0% (0/7) | — | | Chronic gastritis | 30% (29/97) | 268 | | HP gastritis | 15% (15/97) | 536 | | Duodenitis | 1% (2/151) | 7983 | | Increased IEL | 7% (11/151) | 1140 | | Celiac disease | 1% (2/151) | 7983 |
| | Diarrhea | Increased IEL | 7% (6/91) | 1140 | | Celiac disease | 6% (5/91) | 1331 |
| | Nausea and vomiting | Reflux esophagitis | 7% (3/41) | 1117 | | Eosinophilic esophagitis | 2% (1/41) | 3911 | | Chronic gastritis | 24% (20/85) | 335 | | HP gastritis | 6% (5/85) | 1404 |
| | GI bleed | Reflux esophagitis | 0% (0/2) | — | | Chronic gastritis | 27% (8/30) | 298 | | HP gastritis | 10% (3/30) | 803 | | Duodenitis | 5% (1/21) | 1597 |
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The percentages in this table indicate the yield of an abnormality found on a macroscopically normal EGD with a targeted indication.
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