Real-Life Treatment Paradigms Show Adalimumab Is Cost-Effective for the Management of Ulcerative Colitis

Table 2

Health state definitions.

Health state	Definition
Response to medical treatment (steroid/ADA)	Reduction/resolution of symptoms due to patients’ respective treatment regimens. Patients in this cohort would have a UC Disease Activity Index (DAI) score of 0–2 (out of 12) or a partial Mayo score of 0-1 (out of 9).
Unwell	Patients are experiencing recurrent disease activity despite being treated with medical therapy (steroids, 5-ASA, azathioprine, or biologics). Patients in this cohort would have a UC DAI score of 3–8 (out of 12) or a partial Mayo score of 2–6 (out of 9). Symptoms often include 5–8 bowel movements per day, some rectal bleeding, and chronic fecal urgency.
Chronic pouchitis	A common long-term complication after restorative proctocolectomy with ileal pouch-anal anastomosis for patients with UC. Chronic pouchitis is characterized by inflammation of the ileal pouch after surgery, presenting with symptoms of increased stool frequency, urgency, incontinence, and dehydration. In this study, the chronic pouchitis health state refers to chronic pouchitis patients who are refractory to antibiotic therapy to attain remission.
Steroid/ADA complication	Any complication that occurred as a result of the medical treatment (steroid or ADA) that required a change in treatment or health state.
Non-/loss of response (ADA)	Nonresponse refers to patients who never responded to ADA, whereas loss of response refers to patients who experienced an initial response but lost response in subsequent cycles.
Surgery	Proctocolectomy with ileal pouch-anal anastomosis for those patients who did not respond to medical treatment. Typically patients with severe UC undergo surgery in order to manage their disease.
Surgical complication	Any complication that occurred as a result of surgery that requires patient to be hospitalized or to undergo further surgery to correct the complication.