Research Article
Early Esophageal Cancer Specific Survival Is Unaffected by Anatomical Location of Tumor: A Population-Based Study
Table 5
Multivariate Cox proportion hazard regression analyses.
| Variables | 1-year () | 5-year () | HR (95% CI) | value | HR (95% CI) | value |
| Age at diagnosis | 1.01 (0.98–1.05) | 0.53 | 0.99 (0.97–1.02) | 0.53 |
| Sex | | | | | Females | Reference | Reference | Males | 1.07 (0.45–2.55) | 0.53 | 0.79 (0.46–1.36) | 0.40 |
| Marital status | | | Single (never married) | Reference | Reference | Married (including common law) | 2.20 (0.64–7.63) | 0.33 | 1.48 (0.68–3.22) | 0.33 | Divorced/separated/widowed/unmarried or domestic partner | 2.35 (0.59–9.32) | 0.23 | 1.31 (0.54–3.17) | 0.55 | Unknown | 0.00 (0.00–3.48) | 0.78 | 0.48 (0.06–3.99) | 0.50 |
| Race | | | Caucasians | Reference | Reference | African Americans | 1.81 (0.49–6.78) | 0.38 | 1.32 (0.54–3.17) | 0.55 | Others | 2.17 (0.64–7.38) | 0.75 | 0.78 (1.72–3.53) | 0.75 | Unknown | 0.00 (0.00–2.05) | 0.93 | 0.00 (0.00–5.06) | 0.91 |
| Treatment | | | ET | Reference | Reference | EST | 0.64 (0.30–1.37) | 0.25 | 0.71 (0.35–1.44) | 0.34 |
| Location of tumor | | | Lower | Reference | Reference | Middle | 1.39 (0.57–3.37) | 0.47 | 1.26 (0.67–2.39) | 0.47 | Upper | 0.38 (0.05–3.02) | 0.36 | 1.28 (0.52–3.15) | 0.59 |
| Grade of tumor | | | Well-differentiated; grade I | Reference | Reference | Moderately differentiated; grade II | 1.66 (0.61–4.52) | 0.33 | 1.30 (0.62–2.75) | 0.49 | Poorly differentiated; grade III | 1.84 (0.60–5.68) | 0.29 | 1.76 (0.82–3.75) | 0.15 | Undifferentiated; anaplastic; grade IV | 5.27 (0.92–30.21) | 0.06 | 4.12 (1.09–15.62) | 0.04 | B-cell precursor/unknown | 0.58 (0.18–1.90) | 0.37 | 0.77 (0.34–1.74) | 0.52 |
| Size of tumor | | | Entire circumference | Reference | Reference | Microscopic focus only | 0.37 (0.04–3.55) | 0.39 | 0.73 (0.09–6.08) | 0.77 | 2 mm to 990+ mm | 0.17 (0.02–1.33) | 0.09 | 0.45 (0.06–3.33) | 0.43 | No mass | 0.00 (0.00–0.00) | 0.99 | 0.00 (0.00–3.96) | 0.97 |
| Stage of tumor | | | T1a | Reference | Reference | Tis | 2.27 (0.73–7.00) | 0.93 | 1.04 (0.45–2.42) | 0.93 |
| Histology of tumor | | | Adenocarcinoma | Reference | Reference | Squamous cell carcinoma | 1.62 (0.61–4.34) | 0.34 | 1.68 (0.86–3.28) | 0.13 | Others | 0.29 (0.04–2.17) | 0.23 | 0.82 (0.36–1.85) | 0.62 |
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HR: hazard ratio; CI: confidence interval; EET: endoscopic therapy; EST: esophagectomy.
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