|
| Name | Year | Country | Number of patients
(patients included) | Age (range) | Prospective/retrospective | Patient population | Reference standard | Location studied | Pooled analysis
(raw data available) |
|
|
Rieber et al. [13] | 2000 | Germany | 194 (84) | NS | NS | Suspected or established CD | Ileocolonoscopy ± histopathology | Small bowel | No |
|
|
Koh et al. [12] | 2001 | United Kingdom | 30 (21) | 37.6 (18–58) | Prospective | Established CD | Surgery ± ileocolonoscopy | Small and large bowel | No |
|
|
Ochsenkühn et al. [14] | 2004 | Germany | 29 (25) | 31.5 (19–58) | NS | Established CD | Ileocolonoscopy ± histology | Small bowel | Yes |
|
|
Pascu et al. [15] | 2004 | Germany | 61 (37) | 38 (19 to 84) | Prospective | Established CD | Ileocolonoscopy | Small and large bowel | No |
|
|
Schreyer et al. [16] | 2005 | Germany | 30 (23) | 29 (18–65) | Prospective | Established CD | Ileocolonoscopy | Small and large bowel (terminal ileum for analysis) | Yes |
|
|
Maccioni et al. [17] | 2006 | Italy | 70 (59) | 46.3 (18–76) | Prospective | Established CD | Ileocolonoscopy ± imaging | Small and large bowel (ileum for analysis) | Yes |
|
|
Negaard et al. [18] | 2006 | Norway | 60 (41) | 33 (16–65) | NS | Suspected or established CD | Ileocolonoscopy ± surgery | Small bowel (terminal ileum for analysis) | Yes |
|
|
Negaard et al. [19] | 2007 | Norway | 48 (35) | 39 (18–73) | Prospective | Suspected or established CD | Surgery, ileocolonoscopy ± histopathology ± capsule endoscopy | Small bowel | No |
|
|
Seiderer et al. [20] | 2007 | Germany | 10 (10) | 33.9 (17–57) | NS | Suspected CD | Double-balloon enteroscopy (oral route) | Small bowel (jejunum for analysis) | Yes |
|
|
Siddiki et al. [21] | 2009 | USA | 33 (27) | 39 (20–60) | Prospective | Suspected CD | Ileocolonoscopy ± histopathology | Small bowel | Yes |
|
|
Lee et al. [22] | 2009 | South Korea | 31 (23) | 28.8 (18–44) | Prospective | Suspected or established CD | Ileocolonoscopy | Small bowel | Yes |
|
|
Giusti et al. [24] | 2010 | Italy | 70 (70) | 27.8 (15–45) | NS | Established CD | Histopathology | Small bowel | Yes |
|
|
Parisinos et al. [25] | 2010 | United Kingdom | 342 (68) | 36.8 (25–47) | Retrospective | Suspected or established CD | Surgery, ileocolonoscopy ± histopathology | Small bowel | No |
|
|
Fiorino et al. [26] | 2011 | Italy | 44 (44) | 43 (19–61) | Prospective | Established CD | Ileocolonoscopy | Small and large bowel (ileum for analysis) | No |
|
|
Gallego et al. [23] | 2011 | Spain | 61 (61) | 36.1 (14–65) | Prospective | Suspected or established CD | Ileocolonoscopy | Small bowel (ileum for analysis) | Yes |
|
|
Hyun et al. [27] | 2011 | Japan | 30 (25) | 29.5 (24–38) | Prospective | Established CD | Ileocolonoscopy ± double-balloon enteroscopy (rectal route) | Small and large bowel (small bowel for analysis) | Yes |
|
|
Jensen et al. [28] | 2011 | Denmark | 93 (72) | 30 (15–74) | Prospective | Suspected or established CD | Ileocolonoscopy ± surgery | Small bowel | Yes |
|
|
Jensen et al. [29] | 2011 | Denmark | 53 (45) | 39 (18–76) | Prospective | Established CD | Ileocolonoscopy ± surgery | Small bowel | Yes |
|
|
Oto et al. [30] | 2011 | USA | 18 (18) | 33.2 (20–53) | Retrospective | Established CD | Endoscopy ± histopathology | Small bowel | Yes |
|
|
Wiarda et al. [31] |
2012 | Netherlands | 41 (38) | 36 (20–74) | Prospective | Suspected or established CD | Balloon-assisted enteroscopy and consensus | Small bowel | Yes |
|
|
Friedrich et al. [32] | 2012 | Germany | 79 (39) | 27.8 (23–48) | Prospective | Suspected or established CD | Ileocolonoscopy | Small and large bowel (ileum for analysis) | No |
|
|
Grand et al. [33] | 2012 | USA | 310 (310) | 45 (20–94) | Retrospective | Suspected or established CD | Ileocolonoscopy ± histopathology | Small and large bowel | No |
|
|
Adamek et al. [34] | 2012 | Germany | 104 (82) | 39.8 (18–68) | Prospective | Suspected or established CD | Ileocolonoscopy + histopathology | Small bowel (terminal ileum for analysis) | Yes |
|
|
Castiglione et al. [35] | 2013 | Italy | 265 (234) | 39 | Prospective | Suspected CD | Ileocolonoscopy ± surgery | Small bowel | Yes |
|
|
Fallis et al. [36] | 2013 | United Kingdom | 51 (51) | 41.3 (17–79) | Both | Established CD | Surgery | Small and large bowel (distal ileum for analysis) |
Yes1 |
|
|
Takenaka et al. [38] | 2014 | Japan | 100 (100) | 31 (16–71) | Prospective | Established CD | Balloon-assisted enteroscopy (rectal route) | Small bowel (terminal ileum for analysis) | Yes |
|
|
Kumar et al. [37] | 2015 | United Kingdom | 17 (17) | 30.8 (19–72) | Retrospective | Established CD | Surgery | Small bowel | Yes |
|
