Review Article

Magnetic Resonance Imaging of the Small Bowel in Crohn’s Disease: A Systematic Review and Meta-Analysis

Table 2

Imaging characteristics.

NameYearEnterography/
enteroclysis
Magnetic field strengthType of coilBowel preparationIntravenous contrastOral contrastBlindedRadiologist experienceTime interval between MR and RS

Rieber et al. [13]2000EnteroclysisNSNS20 mg IV N-butyl scopolamineGadolinium-DTPA 800 mL barium sulfate solution and 1200 mL methyl cellulose solution NSNSNS

Koh et al. [12]2001Enterography1.0 TNS1 mg IM glucagon 0.1 mmol/kg gadodiamide600 mL waterYesNSMedian 21 days

Ochsenkühn et al. [14]2004Enteroclysis1.5 TNS30–60 mg IV butylscopolamine 0.1 mmol/kg gadolinium-DTPA 1500–2000 mL of a suspension (12 g iron-containing Ferristen) + 20 g methylcellulose (NJ)YesTwo experienced gastrointestinal radiologistsMedian of 10 (3–13) weeks

Pascu et al. [15]2004NS1.5 TBody coilsNS0.2 mmol/kg gadolinium-DTPA NSYesNSWithin 5 days

Schreyer et al. [16]2005Enteroclysis1.5 TPolarized 4-element phased-array body coil40 mg IV N-butyl-scopolamine 0.2 mmol/kg gadolinium-DTPA 1000 mL water (25 g mannitol and 5 g carob seed)YesNSWithin 1 week

Maccioni et al. [17]2006Enterography1.5 TPhased-array coilNS0.18 mmol/kg gadopentetate dimeglumine 600–900 mL ferumoxsil solutionYes>8 years of experience and residentWithin 15 days

Negaard et al. [18]2006Enteroclysis1.5 TPhased-array abdomen surface coil 20 mg IV scopolamine butylbromide 0.1 mmol/kg gadolinium-DTPA 1500–2000 mL polyethylene glycolYesTwo and 1 years of experience with MREWithin 4 months

Negaard et al. [19]2007Both1.5 TPhased-array coils20 mg IV scopolamine butylbromide 0.1 mmol/kg gadolinium-DTPA 1000 mL of 6% mannitol or 1500–2000 mL of polyethylene glycol solution (NJ)Yes>8- and >3-year experienceWithin 3 months

Seiderer et al. [20]2007Enteroclysis1.5 TNS40 mg IV butylscopolammonium bromide 0.1 mmol/kg gadolinium-DTPA 2500 mL 0.5% methylcellulose solution (NJ)NSTwo board-certified radiologistsWithin 6 weeks after MRE

Siddiki et al. [21]2009Enterography1.5 T16-channel torso array coil0.5 mg IV glucagon0.2 mmol/kg gadodiamide 1350 mL barium preparation YesNSWithin 30 days

Lee et al. [22]2009Enterography1.5 TTwo six-element, phased-array body coils20 mg IV scopolamine-N-butyl bromide 15 mL of gadopentetate dimeglumine 1200 mL 3% sorbitol solution and 4000 mL polyethylene glycol solutionYesSix- and 10-year experienceWithin 1 week

Giusti et al. [24]2010Enterography1.5 TTwo phased-array coils 20 mg IV hyoscine-N-butylbromide0.1 mL/kg 1.0 M gadolinium chelate 1500–2000 mL polyethylene glycol solutionYesTwo with >10-year experienceNS

Parisinos et al. [25]2010Enterography1.5 TTwo multichannel phased-array body coils20 mg IV hyoscine-N-butylbromide15 mL of gadolinium chelate 1500 mL of 2.5% mannitol and 0.5% locust bean gum solutionNSNSWithin 8.5 to 112 days

Fiorino et al. [26]2011Enterography1.5 TPhased-array surface coil0.5 mg of glucagon IVGadolinium700 mL polyethylene glycol solutionYesTwo with >8-year experienceWithin 26 days (range 0–37)

Gallego et al. [23]2011Enterography1.0 TMultichannel-body coil 20–40 mg IV hyoscine bromide 0.1 mmol/kg gadopentetate dimeglumine1500 mL polyethylene glycol solutionYesTwo experienced radiologistsWithin 15 days

Hyun et al. [27]2011Enterography1.5 T32-element body coil20 mg IV scopolamine butylbromide 0.2 mL/kg gadolinium chelate1000 mL–1500 mL polyethylene glycol solutionYesTwo board-certified radiologistsSame day

Jensen et al. [28]2011Enterography1.5 TFive-element Syn-body coil20 mg IV Hyoscinbutylbromide 0.1 mmol/kg gadodiamide 1000 mL 7.5% mannitol solutionYesFive with >4-year experienceMedian 13 days

Jensen et al. [29]2011Enterography1.5 TFive-element Syn-body coil20 mg IV Hyoscinbutylbromide 0.1 mmol/kg gadodiamide 1000 mL 7.5% mannitol solutionYesFive with >4-year experienceMedian 11 days (51 days for surgery)

Oto et al. [30]2011Enterography1.5 TFour-channel phased-array body coil1 mg IM glucagon 0.1 mmol/kg gadodiamide1350 mL VolumenNS12 years of experience in body MRIMedian of 14 (0–62) days

Wiarda et al. [31]2012EnteroclysisNSNS20 mg IV butylscopolamine bromide0.1 mmol/kg of gadobutrol 1000–3000 mL 0.5% methylcellulose solution (ND)Yes>200 MRE studiesMedian of 22 (4–112) days

Friedrich et al. [32]2012Enterography1.5 TCircular polarized 6-channel phased-array body coil40 mg IV N-butyl scopolamine0.1 mmol/kg gadolinium-DTPA 1000 mL water (25 g mannitol and 5 g carob seed) and 2000 mL waterYesTwo with 6- and 7-year experienceWithin 3 weeks

Grand et al. [33]2012Enterography1.5 TEight-channel torso array coil or 4-channel surface coil NS0.1 mmol/kg gadopentetate dimeglumine900 mL Volumen Yes>4-year experienceWithin 90 days

Adamek et al. [34]2012Enterography3.0 TTwo surface coils 40 mg IV hyoscine-N-butylbromideGadodiamide1500 to 2000 mL mannitol solutionYes>5-year experienceWithin 7 days

Castiglione et al. [35]2013Enterography3.0 TTwo-paired phased-array body coils20 mg IV N-butylscopolamine 0.2 mmol/kg gadopentetate dimeglumine 1500 mL polyethylene glycol solutionYesTwo expert radiologistsNS

Fallis et al. [36]2013Enterography1.5 TAbdominal phased-array coils20 mg IV hyoscine-N-butylbromide0.2 mL/kg gadoterate meglumine 1200–1300 mL 3% mannitol solutionYesDedicated gastrointestinal radiologistMean 10.8 (1–52) weeks

Takenaka et al. [38]2014Enterography1.5 TNS20 mg IV scopolamine butylbromide0.2 mL/kg gadolinium chelate1000 mL polyethylene glycolYesTwo board-certified radiologistsWithin 3 days

Kumar et al. [37]2015EnterographyNSEight-channel body coil Hyoscine butylbromide 0.2 mL/kg gadolinium250 mL 20% mannitol solutionNSNSMean 77.4 days

NS: not specified; NJ: nasojejunal intubation; ND: nasoduodenal intubation.