VEGF Polymorphisms Related to Higher Serum Levels of Protein Identify Patients with Hepatocellular Carcinoma

Figure 3

Receiver operator characteristic curve (ROC) of serum vascular endothelial growth factor (VEGF) levels in patients with (○) mutant allele of VEGF-C936T in the group with hepatocellular carcinoma (G1) and cirrhosis (G2) (area under the curve = 0.80 ), with sensitivity of 63% and specificity of 93%, to the cut-off value of 311.8 pg/mL; (□) mutant allele of VEGF-C936T in G1 and controls (G3) (area under the curve = 0.89 ), with sensitivity of 75% and specificity of 100%, to the cut-off value of 225.5 pg/mL; (∆) mutant allele of VEGF-A1154G in G1 and G2 (area under the curve = 0.76 ), with sensitivity of 76% and specificity of 65%, to the cut-off value of 222.1 pg/mL.