Possible Involvement of Liver Resident Macrophages (Kupffer Cells) in the Pathogenesis of Both Intrahepatic and Extrahepatic Inflammation

Figure 2

Deletion of Kupffer cells suppresses ConA-induced hepatitis. Con A (27.5 mg/kg) was intravenously injected into control or clodronate-liposome (Clp) treated mice 3 days after liposome treatment. Mice were dissected 24 h after ConA treatment and the ATL activities in the serum were measured (a) and the livers were subjected to histological analysis (b). Real-time PCR was performed using cDNA from the liver in the treated mice for the quantification of IFN-γ, TNF-α, and IL-6 mRNA. .

(a)

(b)

(c)